Evidence map›Paper›PMID 32114117›Full record

ArticleNeuroscience letters2020

The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Na

Nicholas Denomme, April L Lukowski, Jacob M Hull, Margaret B Jameson, Alexandra A Bouza, Alison R H Narayan, Lori L Isom

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. The Plant Alkaloid Harmaline Blocks the Voltage-Gated Sodium Channel NaInternational journal of molecular sciences · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. NaeLife · 2022
    Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nicholas DenommeDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan, 48109 United States; Center for Consciousness Science, University of Michigan, Ann Arbor, Michigan, 48109 United States.
April L LukowskiProgram in Chemical Biology, University of Michigan, Ann Arbor, Michigan, 48109 United States; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, 48109 United States.
Jacob M HullNeuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan, 48109 United States.
Margaret B JamesonDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan, 48109 United States; Molecular and Cellular Pharmacology Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705 United States.
Alexandra A BouzaDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan, 48109 United States.
Alison R H NarayanProgram in Chemical Biology, University of Michigan, Ann Arbor, Michigan, 48109 United States; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, 48109 United States; Department of Chemistry, University of Michigan, Ann Arbor, Michigan, 48109 United States.
Lori L IsomDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan, 48109 United States; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, 48109 United States; Neuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan, 48109 United States; Department of Neurology, University of Michigan, Ann Arbor, Michigan, 48109 United States. Electronic address: lisom@umich.edu.
University of Michigan · USUniversity of Wisconsin–Madison · US

Funding

Role of SCN1B in Inherited EpilepsyR37NS076752 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 2017 to 2023
$4.8M
Undergrad Supplement: Expanding the synthetic utility of natural product biosynthetic enzymesR35GM124880 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alison Narayan · 2017 to 2026
$4.5M
Voltage-gated sodium channel β1 subunit processing: downstream roles in regulating cardiac excitabilityF31HL144047 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOUZA, ALEXANDRA ANN · 2018 to 2019
$64k
Biocatalytic approaches to antiepileptic drug targetsF31NS111906 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUKOWSKI, APRIL · 2019 to 2020
$49k
NHLBI NIH HHS F31 HL144047NIGMS NIH HHS R35 GM124880NINDS NIH HHS F31 NS111906NINDS NIH HHS R37 NS076752
6 · The paper itself

Abstract

Voltage-gated sodium channels (VGSCs) are responsible for the initiation and propagation of action potentials in neurons. The human genome includes ten human VGSC α-subunit genes, SCN(X)A, encoding Na

Indexed as

AnimalsDose-Response Relationship, DrugFemaleHEK293 CellsHumansMaleMiceMice, 129 StrainMice, TransgenicNAV1.1 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelSpecies SpecificityTetrodotoxinVoltage-Gated Sodium Channel BlockersanhydrotetrodotoxinNAV1.1 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelSCN1A protein, humanSCN8A protein, humanTetrodotoxinVoltage-Gated Sodium Channel Blockers4,9-anhydrotetrodotoxinNa(v)1.1Voltage-gated sodium channels

Identifiers

PMID32114117
PMCPMC7096269
OpenAlexW3008751659

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.