SynthesisReproductive biology and endocrinology : RB&E2020
The effectiveness of different down-regulating protocols on in vitro fertilization-embryo transfer in endometriosis: a meta-analysis.
Synthesis in Reproductive biology and endocrinology : RB&E, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Gonadotropin-releasing hormone agonist protocols for pituitary suppression in assisted reproduction.The Cochrane database of systematic reviews · 2025Pooled it
- Systematic review and meta-analysis on the effect of adjuvant gonadotropin-releasing hormone agonist (GnRH-a) on pregnancy outcomes in women with endometriosis following conservative surgery.BMC pregnancy and childbirth · 2024Pooled it
- Role of suppression of endometriosis with progestins before IVF-ET: a non-inferiority randomized controlled trial.BMC pregnancy and childbirth · 2021Trial
- Endometrial Preparation for Frozen-Thawed Embryo Transfer With or Without Pretreatment With GnRH Agonist: A Randomized Controlled Trial at Two Centers.Frontiers in endocrinology · 2021Trial
- Oocyte quality in endometriosis-associated infertility: a narrative analysis of mechanisms and therapeutic options.Molecular biology reports · 2026Review
- Fertility preservation in women with endometriosis: How, when, and for whom?The Journal of international medical research · 2026Article
- Identifying key determinants of cumulative live birth in women with ovarian endometrioma undergoing ethanol sclerotherapy followed byFrontiers in cell and developmental biology · 2026Article
- Current Insights into Endometriosis: Hormonal Management, Clinical Outcomes, and Opportunities for Progress.Current pharmaceutical design · 2026Review
- Development and validation of a clinical nomogram for predicting cumulative live birth rate in ovarian endometrioma patients undergoing ethanol sclerotherapy andFrontiers in endocrinology · 2026Article
- Analysis of risk factors compromising embryo quality and quantity in patients with endometriosis.Frontiers in medicine · 2026Article
- Comparison of vaginal versus intramuscular progesterone in programmed cycles for frozen-thawed blastocyst transfer in patients with endometriosis.Reproductive biology and endocrinology : RB&E · 2025Article
- Adjusting key performance indicators in ART laboratories according to controlled ovarian stimulation protocol.Frontiers in physiology · 2025Article
- Protocols for Endometrial Preparation and Endometrial Pattern Before Embryo Transfer in Patients with Asherman Syndrome.International journal of women's health · 2025Article
- GnRH agonist pretreatment in hormonal endometrial preparation: a comparison of two protocols for frozen embryo transfer outcomes.Frontiers in medicine · 2025Article
- Gonadotropin Releasing Hormone Agonists Combined with Hormone Replacement Therapy Significantly Improves Reproductive Outcomes for Patients with Thin Endometrium and Intramural Fibroids in Frozen Embryo Transfer Cycles.Drug design, development and therapy · 2025Article
- Endometriosis and In Vitro Fertilization.Medicina (Kaunas, Lithuania) · 2024Review
- Review
- Effects of pretreatment strategies on fertility outcomes in patients with adenomyosis.Frontiers in reproductive health · 2024Review
- The effect of gonadotropin-releasing hormone agonist downregulation in conjunction with hormone replacement therapy on endometrial preparation in patients for frozen-thawed embryo transfer.Frontiers in medicine · 2024Article
- Development and validation of a nomogram model for predicting clinical pregnancy in endometriosis patients undergoing fresh embryo transfer.BMC pregnancy and childbirth · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the effectiveness of the GnRH-a ultra-long protocol, GnRH-a long protocol, and GnRH-a short protocol used in in vitro fertilization-embryo transfer (IVF-ET) in infertile women with endometriosis.
methodsWe searched PubMed, Embase, Web of Science, Cochrane Library, Elsevier Science Direct, OA Library, Google Scholar, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, China Science and Technology Journal database, and the China Biology Medicine disc for randomized controlled trials (RCTs) and observational studies (non-RCTs) to evaluate the efficacy of the GnRH-a ultra-long protocol, GnRH-a long protocol, and GnRH-a short protocol in IVF-ET in infertile patients with endometriosis.
resultsA total of 21 studies in compliance with the standard literature were included, and RCT and non-RCT studies were analyzed separately. This meta-analysis showed that the GnRH-a ultra-long protocol could improve the clinical pregnancy rate of infertile patients in RCT studies, especially in patients with stages III-IV endometriosis (RR = 2.04, 95% CI: 1.37~3.04, P < 0.05). However, subgroup analysis found the different down-regulation protocols provided no significant difference in improving clinical outcomes in patients with endometriosis in the non-RCT studies.
conclusionThis study suggests that the GnRH-a ultra-long protocol can improve the clinical pregnancy rate of the patients with stages III-IV endometriosis in RCT studies. Although it is generally believed that the results of RCT are more reliable, the conclusions of the non-RCT studies cannot be easily neglect, which let us draw conclusions more cautious.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.