ArticleMagnetic resonance in medicine2020
Test-retest reliability and long-term stability of three-tissue constrained spherical deconvolution methods for analyzing diffusion MRI data.
Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 39 citations in OpenAlex.
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- A novel fixel-based approach for resolving neonatal white matter microstructure from clinical diffusion MRI.Frontiers in neuroscience · 2026Article
- Diffusion MRI Microstructure Markers of Changes in the Human Brain Across the Lifespan Using Constrained Spherical Deconvolution and Fixel-Based Techniques.Human brain mapping · 2025Article
- Structural determinants of signal speed: Estimated axonal latency and its multimodal validation during face processing in autism.bioRxiv : the preprint server for biology · 2025Article
- Epigenetic age acceleration predicts subject-specific white matter degeneration in the human brain.Aging cell · 2025Article
- Unsupervised Dimensionality Reduction Techniques for the Assessment of ASD Biomarkers.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2025Article
- Widespread associations between behavioral metrics and brain microstructure in ASD suggest age mediates subtypes of ASD.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Conduction Velocity, G-ratio, and Extracellular Water as Microstructural Characteristics of Autism Spectrum Disorder.bioRxiv : the preprint server for biology · 2024Article
- Conduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder.PloS one · 2024Article
- An epigenetic mechanism for differential maturation of amygdala-prefrontal connectivity in childhood socio-emotional development.Translational psychiatry · 2023Article
- Structural brain network lateralization across childhood and adolescence.Human brain mapping · 2023Article
- Diffusion MRI approaches for investigating microstructural complexity in a rat model of traumatic brain injury.Scientific reports · 2023Article
- Alterations in white matter fiber density associated with structural MRI and metabolic PET lesions following multimodal therapy in glioma patients.Frontiers in oncology · 2022Article
- Exercise Training-Related Changes in Cortical Gray Matter Diffusivity and Cognitive Function in Mild Cognitive Impairment and Healthy Older Adults.Frontiers in aging neuroscience · 2021Article
- Fixel-Based Analysis and Free Water Corrected DTI Evaluation of HIV-Associated Neurocognitive Disorders.Frontiers in neurology · 2021Article
- Changes in white matter fiber density and morphology across the adult lifespan: A cross-sectional fixel-based analysis.Human brain mapping · 2020Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeSeveral recent studies have used a three-tissue constrained spherical deconvolution pipeline to obtain quantitative metrics of brain tissue microstructure from diffusion-weighted MRI data. The three tissue compartments, consisting of white matter, gray matter, and CSF-like (free water) signals, are potentially useful in the evaluation of brain microstructure in a range of pathologies. However, the reliability and long-term stability of these metrics have not yet been evaluated.
methodsThis study examined estimates of whole-brain microstructure for the three tissue compartments, in three separate test-retest cohorts. Each cohort had different lengths of time between baseline and retest, ranging from within the same scanning session in the shortest interval to 3 months in the longest interval. Each cohort was also collected with different acquisition parameters.
resultsThe CSF-like compartment displayed the greatest reliability across all cohorts, with intraclass correlation coefficient (ICC) values being above 0.95 in each cohort. White matter-like and gray matter-like compartments both demonstrated very high reliability in the immediate cohort (both ICC > 0.90); however, this declined in the 3-month interval cohort to both compartments having ICC > 0.80. Regional CSF-like signal fraction was examined in bilateral hippocampus and had an ICC > 0.80 in each cohort.
conclusionThe three-tissue constrained spherical deconvolution techniques provide reliable and stable estimates of tissue-microstructure composition, up to 3 months longitudinally in a control population. This forms an important basis for further investigations using three-tissue constrained spherical deconvolution techniques to track changes in microstructure across a variety of brain pathologies.
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