ArticleHepatology (Baltimore, Md.)2020
Activation of Estrogen Receptor G Protein-Coupled Receptor 30 Enhances Cholesterol Cholelithogenesis in Female Mice.
Article in Hepatology (Baltimore, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 40 citations in OpenAlex.
- Understanding pathophysiology of gallstone disease: a multi-omic analysis focused on adult women with obesity.International journal of obesity (2005) · 2026Article
- Article
- Association between relative fat mass and increased prevalence of gallstone disease in American adults: A cross-sectional study.Medicine · 2026Article
- Development and validation of gallstone disease risk factor identification model: a cross-sectional study in Western China.Frontiers in nutrition · 2026Article
- Prognostic value of preoperative serum tumor markers in gallbladder cancer.BMC gastroenterology · 2025Article
- Sex-specific adverse effects of lipid accumulation products and cardiometabolic indices on the prevalence of gallstones: insights from the 2017-2020 national health and nutrition examination survey.BMC gastroenterology · 2025Article
- Positive association between cardiometabolic index and gallstones, with greater impact on women and those younger than 50 years: the NHANES 2017-2020 cross-sectional study.BMC public health · 2025Article
- Association of cardiometabolic index with gallstone disease and insulin resistance based on NHANES data.BMC gastroenterology · 2025Article
- Reply to correspondence 1 on "GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in MASH livers".Clinical and molecular hepatology · 2025Article
- Association between relative fat mass and risk of gallstones in adults.Scientific reports · 2025Article
- Relationship between mucin gene polymorphisms and different types of gallbladder stones.BMC medical genomics · 2025Article
- Sex-related association between smoke exposure and gallstones in a US population: a cross-sectional study.BMC public health · 2025Article
- Burden and risk factors for gallbladder and biliary tract diseases in China from 1990 to 2021 and burden predictions of risk factors for the next 15 years.Frontiers in medicine · 2025Article
- High serum uric acid levels are associated with increased prevalence of gallstones in adult women: a cross-sectional study based on NHANES.Frontiers in medicine · 2025Article
- Association of neutrophil percentage to albumin ratio with gallstones: a cross-sectional study from the United States NHANES.BMC public health · 2024Article
- Ultraprocessed food consumption and risk of gallstone disease: analysis of 3 prospective cohorts.The American journal of clinical nutrition · 2024Article
- Metabolomic profiles of incident gallstone disease.BMJ open gastroenterology · 2024Article
- Current Gallstone Treatment Methods, State of the Art.Diseases (Basel, Switzerland) · 2024Review
- Cholesterol Gallstones and Long-Term Use of Statins: Is Gut Microbiota Dysbiosis Bridging over Uncertainties?Diagnostics (Basel, Switzerland) · 2024Article
- The relationship between high-sensitivity C-reactive protein and gallstones: a cross-sectional analysis.Frontiers in medicine · 2024Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimsEstrogen is an important risk factor for cholesterol gallstone disease because women are twice as likely as men to form gallstones. The classical estrogen receptor α (ERα), but not ERβ, in the liver plays a critical role in the formation of estrogen-induced gallstones in female mice. The molecular mechanisms underlying the lithogenic effect of estrogen on gallstone formation have become more complicated with the identification of G protein-coupled receptor 30 (GPR30), an estrogen receptor. APPROACH AND
resultsWe investigated the biliary and gallstone phenotypes in ovariectomized female GPR30
conclusionsGPR30 produces additional lithogenic actions, working independently of ERα, to increase susceptible to gallstone formation in female mice; both GPR30 and ERα are potential therapeutic targets for cholesterol gallstone disease, particularly in women and patients exposed to high levels of estrogen.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.