ReviewGenes & genomics2020
Type three secretion system in Salmonella Typhimurium: the key to infection.
Review in Genes & genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Genomic characterization and comparative analysis of multidrug-resistantFrontiers in veterinary science · 2026Article
- Novel Animal Model of Enterobacteria Pathogenicity, Virulence, and Amoxicillin-Biosurfactant Synergic Using Nsombé (Rhynchophorus phoenicis Larvae).MicrobiologyOpen · 2025Article
- Targeted genome mining with GATOR-GC maps the evolutionary landscape of biosynthetic diversity.Nucleic acids research · 2025Article
- A tale of two caspases.eLife · 2025Article
- Targeted genome mining with GATOR-GC maps the evolutionary landscape of biosynthetic diversity.bioRxiv : the preprint server for biology · 2025Article
- Potential Convergence to Accommodate Pathogenicity Determinants and Antibiotic Resistance Revealed inMicroorganisms · 2024Article
- ESBL-Type and AmpC-Type Beta-Lactamases in Third Generation Cephalosporin-ResistantAnimals : an open access journal from MDPI · 2024Article
- Fisetin inhibitsMicrobiology spectrum · 2024Article
- A host E3 ubiquitin ligase regulatesmLife · 2023Article
- Human Salmonellosis: A Continuous Global Threat in the Farm-to-Fork Food Safety Continuum.Foods (Basel, Switzerland) · 2023Review
- Salmonella Typhimurium expressing chromosomally integrated Schistosoma mansoni Cathepsin B protects against schistosomiasis in mice.NPJ vaccines · 2023Article
- Functions of Small Non-Coding RNAs inBiology · 2022Review
- Nucleic Acid-Based Nanobiosensor (NAB) Used forNanomaterials (Basel, Switzerland) · 2022Review
- Label-free relative quantitative proteomics reveals extracellular vesicles as a vehicle forFrontiers in microbiology · 2022Article
- Involvement of the Heat Shock Protein HtpG ofFrontiers in cellular and infection microbiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundType Three Secretion Systems (T3SS) are nanomachine complexes, which display the ability to inject effector proteins directly into host cells. This skill allows for gram-negative bacteria to modulate several host cell responses, such as cytoskeleton rearrangement, signal transduction, and cytokine production, which in turn increase the pathogenicity of these bacteria. The Salmonella enterica subsp. enterica serovar Typhimurium (ST) T3SS has been the most characterized so far. Among gram-negative bacterium, ST is one of enterica groups predicted to have two T3SSs activated during different phases of infection.
objectiveTo comprise current information about ST T3SS structure and function as well as an overview of its assembly and hierarchical regulation.
methodsWith a brief and straightforward reading, this review summarized aspects of both ST T3SS, such as its structure and function. That was possible due to the development of novel techniques, such as X-ray crystallography, cryoelectron microscopy, and nano-gold labelling, which also elucidated the mechanisms behind T3SS assembly and regulation, which was addressed in this review.
conclusionThis paper provided fundamental overview of ST T3SS assembly and regulation, besides summarized the structure and function of this complex. Due to T3SS relevance in ST pathogenicity, this complex could become a potential target in therapeutic studies as this nanomachine modulates the infection process.
Indexed as
Identifiers
32112371What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.