Evidence map›Paper›PMID 32112365›Full record

Trial reportOdontology2020

Effect of topical administration of propolis in chronic periodontitis.

Ryoma Nakao, Hidenobu Senpuku, Makoto Ohnishi, Hideki Takai, Yorimasa Ogata

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Odontology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.

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  11. Multimodal inhibitory effect of matcha onMicrobiology spectrum · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ryoma NakaoDepartment of Bacteriology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan. ryoma73@nih.go.jp.ORCID http://orcid.org/0000-0002-4802-8518
Hidenobu SenpukuDepartment of Bacteriology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
Makoto OhnishiDepartment of Bacteriology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
Hideki TakaiDepartment of Periodontology, Nihon University School of Dentistry at Matsudo, Chiba, Japan.
Yorimasa OgataDepartment of Periodontology, Nihon University School of Dentistry at Matsudo, Chiba, Japan.
National Institute of Infectious Diseases · JPNihon University · JP

Funding

the Japan Society for the Promotion of Science KAKENHI JP26462866the Urakami Foundation for Food and Food Culture Promotion NAYamada Research Grant 0163 and 0186
6 · The paper itself

Abstract

To investigate the effect of topical administration of propolis (a honeybee product) or curry leaf (an herbal product) into the periodontal pockets of periodontitis patients, a double-blind controlled clinical trial was conducted with 24 subjects including one drop-out diagnosed with moderate-to-advanced chronic periodontitis who completed initial periodontal therapy. They were randomly allocated to the following treatments: placebo, propolis, curry leaf, and minocycline. Gingival crevicular fluid (GCF) samples collected before and after the intervention were analyzed to quantify the number of total bacteria and number of six major periodontopathic bacteria by real-time PCR. Periodontitis-related clinical parameters were also analyzed. Among the six propolis-treated patients whose GCF samples were P. gingivalis-positive, three patients converted to be P. gingivalis-negative after the intervention. The minocycline-treated group exhibited a decrease in probing pocket depth (PPD) with statistically significant improvement, but not gain of clinical attachment level (CAL). Both PPD and CAL have been improved in the propolis-treated group at a statistically significant level, but not the curry leaf-treated group. In conclusion, treatment with propolis significantly improved both PPD and CAL, together with a tendency towards reduced P. gingivalis burden in GCF. It is likely that a propolis-based therapy becomes an alternative treatment option for chronic periodontitis during supportive periodontal therapy.

Indexed as

Chronic PeriodontitisPropolisAdministration, TopicalAnimalsDental ScalingGingival Crevicular FluidHumansPeriodontal Attachment LossPeriodontal IndexPropolisAdjunctive therapyPeriodontal pocketPeriodontitisPorphyromonas gingivalisPropolis

Identifiers

PMID32112365
OpenAlexW3007712749

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.