Evidence map›Paper›PMID 32112355›Full record

ArticleEnvironmental science and pollution research international2020

The effect of aryl hydrocarbon receptor ligands on gentamicin-induced nephrotoxicity in rats.

Mahmoud Mohamed Mokhtar, Emad Gamil Khidr, Hesham Mohamed Shaban, Shady Allam, Bakheet E M Elsadek, Salama Abdou Salama, Shawkey Saddik Ali

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In one paragraph

Article in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mahmoud Mohamed MokhtarBiochemistry Department-Faculty of Pharmacy (Boys), Al-Azhar University, Almokhayam Aldaem Street, 6th Province, Nasr City, Cairo, 13465, Egypt. Mahmoud.Mokhtar@Azhar.edu.eg.ORCID http://orcid.org/0000-0001-6862-5662
Emad Gamil KhidrBiochemistry Department-Faculty of Pharmacy (Boys), Al-Azhar University, Almokhayam Aldaem Street, 6th Province, Nasr City, Cairo, 13465, Egypt.
Hesham Mohamed ShabanBiochemistry Department-Faculty of Pharmacy (Boys), Al-Azhar University, Almokhayam Aldaem Street, 6th Province, Nasr City, Cairo, 13465, Egypt.
Shady AllamPharmacology and Toxicology Department-Faculty of Pharmacy, Kafrelsheikh University, Kafr El Sheikh, Egypt.
Bakheet E M ElsadekBiochemistry Department-Faculty of Pharmacy (Boys), Assuit Branch, Al-Azhar University, Assuit, Egypt.
Salama Abdou SalamaPharmacology and Toxicology Department-Faculty of Pharmacy (Boys), Al-Azhar University, Almokhayam Aldaem Street, 6th Province, Nasr City, Cairo, 13465, Egypt.
Shawkey Saddik AliBiochemistry Department-Faculty of Pharmacy (Boys), Al-Azhar University, Almokhayam Aldaem Street, 6th Province, Nasr City, Cairo, 13465, Egypt.
Al-Azhar University · EGKafrelsheikh University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycyclic aromatic hydrocarbons (PAHs)/aryl hydrocarbon receptor (AhR) regulate the expression of target genes, including drug transporter genes which harbor xenobiotic response element (XRE) in their promoter regions. Thus, PAHs/AhR could alter the toxicokinetic profile of many nephrotoxic drugs, including aminoglycosides. In the current study, we investigated the expression and localization of AhR and megalin in rat kidney. Furthermore, we investigated whether AhR and its ligands could modulate the expression of megalin and consequently the gentamicin-induced nephrotoxicity (GN) in rats. Both megalin and AhR receptors are expressed in the proximal tubules of the rat kidney. Treatment with AhR agonist benzo(a)pyrene aggravated GN as indicated by a significant increase in serum creatinine, BUN, KIM1, NAGL, CD-86, and urinary albumin/creatinine ratio. On the other hand, treatment with AhR antagonist resveratrol ameliorated GN as manifested by a pronounced decrease in the aforementioned parameters. The effects of AhR ligands on GN were associated with altered expression of megalin receptor.

Indexed as

Polycyclic Aromatic HydrocarbonsReceptors, Aryl HydrocarbonAnimalsBenzo(a)pyreneGentamicinsLigandsRatsBenzo(a)pyreneGentamicinsLigandsPolycyclic Aromatic HydrocarbonsReceptors, Aryl HydrocarbonAhRBenzo(a)pyreneGentamicinMegalinNephrotoxicityPAHSResveratrol

Identifiers

PMID32112355
OpenAlexW3007385870

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.