Evidence map›Paper›PMID 32112300›Full record

ReviewMolecular biology reports2020

Alterations of cell cycle genes in cancer: unmasking the role of cancer stem cells.

Hasan Onur Caglar, Cigir Biray Avci

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 52 citations in OpenAlex.

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  9. Cancer biology & therapy · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hasan Onur CaglarDepartment of Stem Cell, Health Science Institute, Ege University, Bornova, 35100, Izmir, Turkey.
Cigir Biray AvciDepartment of Medical Biology, Medical Faculty, Ege University, Bornova, 35100, Izmir, Turkey. cbavci@gmail.com.
Ege University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cell cycle is a complex and strictly controlled process, consisting of different phases. Cell cycle regulation depends on phase-specific transcriptions of cell cycle genes. The alterations of cell cycle genes can predispose normal cells to have a cancerous phenotype. Indeed, several mechanisms underlying the deregulation of the cell cycle have been identified in different types of cancer. Cancer stem cells (CSCs), a fraction of tumor cells, are selectively capable of initiating tumor development. However, the deregulation of the cell cycle progression in CSCs still remains incompletely understood. This review describes epigenetic alterations and aberrant transcriptional regulation of cell cycle genes in CSCs as well as cell cycle patterns of CSCs.

Indexed as

Cell CycleCell Cycle CheckpointsCell Cycle ProteinsCell DivisionCyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent KinasesCyclinsGenes, cdcHumansNeoplasmsNeoplastic Stem CellsCell Cycle ProteinsCyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent KinasesCyclinsBmi-1CancerCancer stem cellsCell cycleCyclin-dependent kinase inhibitorsCyclin-dependent kinasesCyclins

Identifiers

PMID32112300
OpenAlexW3007305222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.