Evidence map›Paper›PMID 32112196›Full record

Trial reportArchives of osteoporosis2020

Osteoporosis screening using computed tomography for men with prostate cancer: results of a prospective study.

Andrew M McDonald, Eddy S Yang, Kenneth G Saag, Emily B Levitan, Nicole C Wright, John B Fiveash, Soroush Rais-Bahrami, Smita Bhatia

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of osteoporosis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Andrew M McDonaldDepartment of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USA. ammcdonald@uabmc.edu.
Eddy S YangDepartment of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.
Kenneth G SaagDivision of Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Emily B LevitanDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Nicole C WrightDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
John B FiveashDepartment of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.
Soroush Rais-BahramiDepartment of Urology, University of Alabama at Birmingham, Birmingham, AL, USA.
Smita BhatiaInstitute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · US

Funding

National Dissemination of I-Corps@NCATS: Accelerating Translation through CommercializationUL1TR003096 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M, KIMBERLY, ROBERT P. · 2019 to 2023
$43.6M
Biology or Management: Understanding Racial Differences in Post Fracture OutcomesK01AR068400 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WRIGHT, NICOLE C · 2017 to 2020
$508k
NCATS NIH HHS UL1 TR003096NIAMS NIH HHS K01 AR068400
6 · The paper itself

Abstract

We performed a prospective study using both FRAX and computed tomography to screen for osteoporosis in men undergoing radiation for prostate cancer. We found that implementing routine computed tomography (CT)-based screening was feasible in the setting of a prospective study, but the yield of osteoporosis identification was low in this population. PURPOSE: Men with prostate cancer (PCa) are at increased risk of hip fracture for multiple reasons. Estimation of hip fracture risk with the FRAX tool is currently recommended, but FRAX alone may not identify a portion of men with osteoporosis. We hypothesized that adding bone mineral density (BMD) screening using CT to FRAX is feasible and would identify more men with osteoporosis.

methodsMen with PCa scheduled to undergo CT simulation for radiation treatment were enrolled in a single-arm prospective study. The mean attenuation of the mid-L5 vertebral body trabecular bone (L5

resultsA total of 98 eligible men were enrolled and underwent FRAX and CT screening. The median 10-year risk of hip fracture was 1.1% and exceeded 3% in 16 cases; the median L5

conclusionsImplementing CT-based BMD screening was feasible in the setting of a prospective study for men receiving radiation for PCa, but fewer cases than anticipated of osteoporosis were identified.

Indexed as

Absorptiometry, PhotonAdultAgedAged, 80 and overAlgorithmsBone DensityCancellous BoneFeasibility StudiesHip FracturesHumansMaleMass ScreeningMiddle AgedOsteoporosisProspective StudiesProstatic NeoplasmsComputed tomographyOpportunistic screeningProstate cancer

Identifiers

PMID32112196
PMCPMC7402416
OpenAlexW3012150614

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.