ArticleAmerican journal of clinical pathology2020
Histologic and Laboratory Characteristics of Symptomatic and Asymptomatic Castleman Disease in the Pediatric Population.
Article in American journal of clinical pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- The clinical picture of Castleman disease: a systematic review and meta-analysis.Blood advances · 2024Pooled it
- Off-label use of canakinumab in pediatric rheumatology and rare diseases.Frontiers in medicine · 2022Pooled it
- Paraneoplastic pemphigus and Castleman's disease: a case report and a revision of the literature.Italian journal of pediatrics · 2023Article
- Transcriptome and unique cytokine microenvironment of Castleman disease.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Article
- Pediatric Lymphoid and Histiocytic Lesions in the Head and Neck.Head and neck pathology · 2021Review
- Unicentric Portocaval Castleman Disease in an Adolescent: Challenges in Diagnosis and Management.Journal of Indian Association of Pediatric SurgeonsArticle
- Hyaline Vascular Castleman Disease Presenting as Occipital Scalp Swelling in a Child.Journal of Indian Association of Pediatric SurgeonsArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesCompare the morphologic, laboratory, and clinical features of asymptomatic and symptomatic Castleman disease in the pediatric population.
methodsWe reviewed clinical records and histopathology of patients with Castleman disease from 2 pediatric institutions.
resultsOf 39 patients with pediatric Castleman disease, 37 had unicentric disease, all classified with the hyaline vascular variant of Castleman disease, 8 of which were clinically symptomatic. These 8 patients demonstrated abnormal laboratory findings, including microcytic anemia, elevated erythrocyte sedimentation rate and C-reactive protein, and hypoalbuminemia. In addition, histopathologic evaluation showed that the 8 symptomatic cases had more hyperplastic germinal centers, fewer atrophic or regressed germinal centers, fewer mantle zones containing multiple germinal centers, reduced "onion skinning" of mantle zones, and fewer "lollipop" formations compared with the asymptomatic cases.
conclusionsThis series of pediatric Castleman disease showed that lymph nodes from asymptomatic patients generally demonstrated the more classic hyaline vascular histology, whereas those with symptoms could lack or have only focal classic findings. As such, reactive lymph nodes with subtle Castleman-like features should prompt clinical correlation to ensure proper diagnosis.
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