Evidence map›Paper›PMID 32112047›Full record

ArticleMucosal immunology2020

IL-17 production by tissue-resident MAIT cells is locally induced in children with pneumonia.

Bingtai Lu, Ming Liu, Jun Wang, Huifeng Fan, Diyuan Yang, Li Zhang, Xiaoqiong Gu, Junli Nie, Zhenjun Chen, Alexandra J Corbett and 10 more

Open access · hybridAbstract read
In one paragraph

Article in Mucosal immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 104 citations in OpenAlex.

  1. Article
  2. Observational
  3. MAIT cell plasticity generates CD4Cellular & molecular immunology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Metabolic control of innate-like T cells.Nature reviews. Immunology · 2026
    Review
  8. Review
  9. Article
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  11. Review
  12. Article
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  14. Article
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  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 2 countries.

Bingtai Lu *Department of Respiratory Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Centre, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong, China.
Ming Liu *Department of Respiratory Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Centre, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong, China.
Jun Wang *Department of Respiratory Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Centre, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong, China.
Huifeng Fan *Department of Respiratory Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Centre, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong, China.
Diyuan YangDepartment of Respiratory Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Centre, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong, China.
Li ZhangDepartment of Respiratory Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Centre, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong, China.
Xiaoqiong GuDepartment of Respiratory Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Centre, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong, China.
Junli NieDepartment of Respiratory Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Centre, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong, China.
Zhenjun ChenDepartment of Immunology and Microbiology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.
Alexandra J CorbettDepartment of Immunology and Microbiology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.
Michael J ZhanThe Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia.
Shengbo ZhangWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Vanessa L BryantWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Andrew M LewDepartment of Immunology and Microbiology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.
James McCluskeyDepartment of Immunology and Microbiology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.
Hai-Bin LuoSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China.
Jun CuiSchool of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China.
Yuxia ZhangDepartment of Respiratory Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Centre, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong, China. yuxia.zhang@gwcmc.org.
Yifan ZhanDepartment of Respiratory Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Centre, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong, China. zhan@WEHI.edu.au.
Gen LuDepartment of Respiratory Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Centre, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong, China. lugen5663330@sina.com.
Guangzhou Medical University · CNState Key Laboratory of Respiratory Disease · CNPeter Doherty Institute · AUWalter and Eliza Hall Institute of Medical Research · AUSun Yat-sen University · CNUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Community-acquired pneumonia (CAP) contributes substantially to morbidity and mortality in children under the age of 5 years. In examining bronchoalveolar lavages (BALs) of children with CAP, we found that interleukin-17 (IL-17) production was significantly increased in severe CAP. Immune profiling showed that mucosal-associated invariant T (MAIT) cells from the BALs, but not blood, of CAP patients actively produced IL-17 (MAIT17). Single-cell RNA-sequencing revealed that MAIT17 resided in a BAL-resident PLZF

Indexed as

AnimalsBiomarkersChildCytokinesDisease Models, AnimalDisease SusceptibilityFemaleGene Expression ProfilingHumansImmunophenotypingInflammation MediatorsInterleukin-17Lymphocyte ActivationMaleMiceMonocytesBiomarkersCytokinesIL17A protein, humanInflammation MediatorsInterleukin-17Transcription Factors

Identifiers

PMID32112047
PMCPMC7434594
OpenAlexW3007219306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.