Evidence map›Paper›PMID 32112046›Full record

ReviewMucosal immunology2020

Host responses to mucosal biofilms in the lung and gut.

Jada C Domingue, Julia L Drewes, Christian A Merlo, Franck Housseau, Cynthia L Sears

Open access · bronzeAbstract readReview
In one paragraph

Review in Mucosal immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 65 citations in OpenAlex.

  1. Modeling chronic infection withInfection and immunity · 2026
    Article
  2. Adaptation ofmSystems · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Ultrasound-Mediated Antibiotic Delivery to In Vivo Biofilm Infections: A Review.Chembiochem : a European journal of chemical biology · 2024
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. The Role of the Gut Microbiome in Cancer: A Review, With Special Focus on Colorectal Neoplasia and Clostridioides difficile.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jada C DomingueJohns Hopkins University School of Medicine, Division of Infectious Diseases, Baltimore, MD, USA.
Julia L DrewesJohns Hopkins University School of Medicine, Division of Infectious Diseases, Baltimore, MD, USA.
Christian A MerloJohns Hopkins University School of Medicine, Division of Pulmonary Medicine, Baltimore, MD, USA.
Franck HousseauJohns Hopkins University School of Medicine, Bloomberg~Kimmel Institute for Cancer Immunotherapy, Baltimore, MD, USA.
Cynthia L SearsJohns Hopkins University School of Medicine, Division of Infectious Diseases, Baltimore, MD, USA. csears@jhmi.edu.
Johns Hopkins University · USBloomberg (United States) · US

Funding

Molecular, Cellular and Tissue Characterization UnitU2CCA233291 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 2018 to 2023
$12.2M
Biofilm Epidemiology and Mechanisms in Colon CancerR01CA196845 · NCI · JOHNS HOPKINS UNIVERSITY · PI GIARDIELLO, FRANCIS M, SEARS, CYNTHIA · 2016 to 2020
$4.3M
Correlates of antitumor immunity in colorectal cancers and anti PD1 therapyR01CA203891 · NCI · JOHNS HOPKINS UNIVERSITY · PI HOUSSEAU, FRANCK · 2016 to 2020
$1.9M
Characterization of microbial and host requirements for colonic biofilm assembly and biofilm-mediated colon tumorigenesisK99CA230192 · NCI · JOHNS HOPKINS UNIVERSITY · PI DREWES, JULIA L · 2018 to 2019
$179k
Cancer Research UKNCI NIH HHS K99 CA230192NCI NIH HHS R01 CA196845NCI NIH HHS R01 CA203891NCI NIH HHS U2C CA233291
6 · The paper itself

Abstract

The impact of the human microbiome on health and disease is of utmost importance and has been studied intensively in recent years. Microbes promote immune system development and are essential to the production and absorption of nutrients for the host but are also implicated in disease pathogenesis. Particularly, bacterial biofilms have long been recognized as contributors to chronic infections and diseases in humans. However, our understanding of how the host responds to the presence of biofilms, specifically the immune response to biofilms, and how this contributes to disease pathogenesis is limited. This review aims to highlight what is known about biofilm formation and in vivo models available for the biofilm study. We critique the contribution of biofilms to human diseases, focusing on the lung diseases, cystic fibrosis and chronic obstructive pulmonary disease, and the gut diseases, inflammatory bowel disease and colorectal cancer.

Indexed as

BiofilmsAnimalsDisease SusceptibilityGastrointestinal MicrobiomeHost-Pathogen InteractionsHumansImmunity, MucosalInflammatory Bowel DiseasesMicrobiotaModels, BiologicalRespiratory Mucosa

Identifiers

PMID32112046
PMCPMC8323778
OpenAlexW3007208368

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.