ArticleScientific reports2020
Characterization of the Airflow within an Average Geometry of the Healthy Human Nasal Cavity.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- HUG-VAS: A Hierarchical NURBS-Based Generative Model for Aortic Geometry Synthesis and Controllable Editing.Computer methods in applied mechanics and engineering · 2026Article
- CFD-Enabled Deep Insert Nasal Delivery for Precision Sinus Targeting.Pharmaceutical research · 2026Article
- Development, Fabrication and Application of a Sectioned 3D-Printed Human Nasal Cavity Model for In Vitro Nasal Spray Deposition Studies.Biomedicines · 2026Article
- Deposition of Occupational Aerosol Particles in a Three-Dimensional Adult Nasal Cavity Model: An Experimental Study.Bioengineering (Basel, Switzerland) · 2026Article
- Asymmetry from an asymmetrical cannula interface and nasogastric tube during nasal high flow enhances dead-space clearance: a fluid dynamics study.Frontiers in medicine · 2026Article
- Intranasal biomaterials for treatment-resistant depression: device-formulation coupling and therapeutic exposure.Frontiers in bioengineering and biotechnology · 2026Article
- Standardization of nasal airway structure model of Chinese Han nationality for characterization of nasal formulation spatial deposition atlases.Acta pharmaceutica Sinica. B · 2025Article
- Creating nasal cycle simulations by processing MRI and CT scan data with image morphing algorithms.Scientific reports · 2025Article
- Computational Rhinology: Unraveling Discrepancies between In Silico and In Vivo Nasal Airflow Assessments for Enhanced Clinical Decision Support.Bioengineering (Basel, Switzerland) · 2024Review
- On the comparison between pre- and post-surgery nasal anatomies via computational fluid dynamics.Biomechanics and modeling in mechanobiology · 2024Article
- Asymmetrical high-flow nasal cannula performs similarly to standard interface in patients with acute hypoxemic post-extubation respiratory failure: a pilot study.BMC pulmonary medicine · 2024Article
- Laminar Fluid Ejection for Olfactory Drug Delivery: A Proof of Concept Study.IEEE journal of translational engineering in health and medicine · 2024Article
- The Path from Nasal Tissue to Nasal Mucosa on Chip: Part 2-Advanced Microfluidic Nasal In Vitro Model for Drug Absorption Testing.Pharmaceutics · 2023Article
- Computational optimization of delivery parameters to guide the development of targeted Nasal spray.Scientific reports · 2023Article
- Numerical and Experimental Analysis of Drug Inhalation in Realistic Human Upper Airway Model.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Asymmetrical nasal high flow ventilation improves clearance of COJournal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Comparison of rhinomanometric and computational fluid dynamic assessment of nasal resistance with respect to measurement accuracy.International journal of computer assisted radiology and surgery · 2022Article
- Effect of respiratory rate and size of cannula on pressure and dead-space clearance during nasal high flow in patients with COPD and acute respiratory failure.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- CT-Based Analysis of Left Ventricular Hemodynamics Using Statistical Shape Modeling and Computational Fluid Dynamics.Frontiers in cardiovascular medicine · 2022Article
- Human Multi-CompartmentFrontiers in physiology · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study's objective was the generation of a standardized geometry of the healthy nasal cavity. An average geometry of the healthy nasal cavity was generated using a statistical shape model based on 25 symptom-free subjects. Airflow within the average geometry and these geometries was calculated using fluid simulations. Integral measures of the nasal resistance, wall shear stresses (WSS) and velocities were calculated as well as cross-sectional areas (CSA). Furthermore, individual WSS and static pressure distributions were mapped onto the average geometry. The average geometry featured an overall more regular shape that resulted in less resistance, reduced WSS and velocities compared to the median of the 25 geometries. Spatial distributions of WSS and pressure of the average geometry agreed well compared to the average distributions of all individual geometries. The minimal CSA of the average geometry was larger than the median of all individual geometries (83.4 vs. 74.7 mm²). The airflow observed within the average geometry of the healthy nasal cavity did not equal the average airflow of the individual geometries. While differences observed for integral measures were notable, the calculated values for the average geometry lay within the distributions of the individual parameters. Spatially resolved parameters differed less prominently.
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