ArticleScientific reports2020
Gradient acoustic focusing of sub-micron particles for separation of bacteria from blood lysate.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Isolating viable bacteria from positive blood cultures: impedance cytometry analysis.Biomedical microdevices · 2026Article
- Recent Advances in Bacterial Separation and Enrichment from Blood for the Diagnosis of Bloodstream Infections.Sensors (Basel, Switzerland) · 2026Review
- Acoustic Streaming-Based 3D Cell Focusing and Plasma Separation.Micromachines · 2026Article
- Inhomogeneous Fluid Motion Induced by Standing Surface Acoustic Wave (SAW): A Finite Element Study.Micromachines · 2026Article
- Acoustofluidic Plasmapheresis System Designed for Ultralow Blood Volume Applications.Analytical chemistry · 2026Article
- Thermoacoustic streaming in a linear temperature gradient.Physical review. E · 2025Article
- Acoustophoretic Characterization and Separation of Blood Cells in Acoustic Impedance Gradients.Physical review applied · 2023Article
- Characterization of bacteria swarming effect under plasmonic optical fiber illumination.Journal of biomedical optics · 2023Article
- Biomolecular actuators for genetically selective acoustic manipulation of cells.Science advances · 2023Article
- Diagnosis of Bloodstream Infections: An Evolution of Technologies towards Accurate and Rapid Identification and Antibiotic Susceptibility Testing.Antibiotics (Basel, Switzerland) · 2022Review
- Recent advances in acoustofluidic separation technology in biology.Microsystems & nanoengineering · 2022Review
- Numerical and experimental analysis of a hybrid material acoustophoretic device for manipulation of microparticles.Scientific reports · 2021Article
- Acoustofluidic medium exchange for preparation of electrocompetent bacteria using channel wall trapping.Lab on a chip · 2021Article
- Fast Microscale Acoustic Streaming Driven by a Temperature-Gradient-Induced Nondissipative Acoustic Body Force.Physical review letters · 2021Article
- Plasmonic optical fiber for bacteria manipulation-characterization and visualization of accumulation behavior under plasmo-thermal trapping.Biomedical optics express · 2021Article
- 3D numerical simulation of acoustophoretic motion induced by boundary-driven acoustic streaming in standing surface acoustic wave microfluidics.Scientific reports · 2021Article
- Field-Portable Microplastic Sensing in Aqueous Environments: A Perspective on Emerging Techniques.Sensors (Basel, Switzerland) · 2021Article
- Acoustofluidic separation enables early diagnosis of traumatic brain injury based on circulating exosomes.Microsystems & nanoengineering · 2021Article
- Contactless acoustic micro/nano manipulation: a paradigm for next generation applications in life sciences.Proceedings. Mathematical, physical, and engineering sciences · 2020Review
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Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Handling of submicron-sized objects is important in many biochemical and biomedical applications, but few methods today can precisely manipulate this range of particles. We present gradient acoustic focusing that enables flow-through particle separation of submicron particles and cells and we apply it for separation of bacteria from blood lysate to facilitate their detection in whole blood for improved diagnostics. To control suspended objects below the classical 2µm size limit for acoustic focusing, we introduce a co-flowing acoustic impedance gradient to generate a stabilizing acoustic volume force that supresses acoustic streaming. The method is validated theoretically and experimentally using polystyrene particles, Staphylococcus aureus, Streptococcus pneumoniae and Escherichia coli. The applicability of the method is demonstrated by the separation of bacteria from selectively chemically lysed blood. Combined with downstream operations, this new approach opens up for novel methods for sepsis diagnostics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.