ArticleNature communications2020
Quantum scale organic semiconductors for SERS detection of DNA methylation and gene expression.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Probing Biointerfaces with QCM‑D and Electrochemistry: Opportunities and Challenges toward Integrated EQCM‑D Biosensing.ACS measurement science au · 2026Review
- Plasmonic Molecular Entrapment for Label-Free Methylated DNA Detection and Machine-Learning Assisted Quantification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Label-Free Surface-Enhanced Raman Scattering for Genomic DNA Cytosine Methylation Reading.Molecules (Basel, Switzerland) · 2025Article
- Tuning Nanographene-Enhanced Raman Scattering for Rapid Label-Free Detection of Amino Acids.ACS applied materials & interfaces · 2024Article
- Multiple valence states of Fe boosting SERS activity of FeFundamental research · 2024Article
- SERS biosensors for liquid biopsy towards cancer diagnosis by detection of various circulating biomarkers: current progress and perspectives.Nano convergence · 2024Review
- Nano-biosensor for SARS-CoV-2/COVID-19 detection: methods, mechanism and interface design.RSC advances · 2023Review
- Recent development of surface-enhanced Raman scattering for biosensing.Journal of nanobiotechnology · 2023Review
- Decoding the metabolic response ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- CanMethdb: a database for genome-wide DNA methylation annotation in cancers.Bioinformatics (Oxford, England) · 2023Article
- Nanomaterials meet surface-enhanced Raman scattering towards enhanced clinical diagnosis: a review.Journal of nanobiotechnology · 2022Review
- Optical bio-sensing of DNA methylation analysis: an overview of recent progress and future prospects.RSC advances · 2022Review
- An Epigenetic Role of Mitochondria in Cancer.Cells · 2022Review
- Recent Advances in Inflammatory Diagnosis with Graphene Quantum Dots Enhanced SERS Detection.Biosensors · 2022Review
- A bioinspired hollow g-CChemical science · 2022Article
- Detection and discrimination of SARS-CoV-2 spike protein-derived peptides using THz metamaterials.Biosensors & bioelectronics · 2022Article
- Defect engineering in semiconductor-based SERS.Chemical science · 2022Review
- Recent advances in plasmonic Prussian blue-based SERS nanotags for biological application.Nanoscale advances · 2021Review
- Dual-modality loop-mediated isothermal amplification for pretreatment-free detection of Septin9 methylated DNA in colorectal cancer.Mikrochimica acta · 2021Article
- Surface Enhanced Raman Scattering Revealed by Interfacial Charge-Transfer Transitions.Innovation (Cambridge (Mass.)) · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer stem cells (CSC) can be identified by modifications in their genomic DNA. Here, we report a concept of precisely shrinking an organic semiconductor surface-enhanced Raman scattering (SERS) probe to quantum size, for investigating the epigenetic profile of CSC. The probe is used for tag-free genomic DNA detection, an approach towards the advancement of single-molecule DNA detection. The sensor detected structural, molecular and gene expression aberrations of genomic DNA in femtomolar concentration simultaneously in a single test. In addition to pointing out the divergences in genomic DNA of cancerous and non-cancerous cells, the quantum scale organic semiconductor was able to trace the expression of two genes which are frequently used as CSC markers. The quantum scale organic semiconductor holds the potential to be a new tool for label-free, ultra-sensitive multiplexed genomic analysis.
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