ArticleNature communications2020
Adverse caregiving in infancy blunts neural processing of the mother.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 37 citations in OpenAlex.
- Early adversity alters neurodevelopmental milestones in male and female rat pups and motor cortex morphology and gait in juveniles.Neurobiology of stress · 2026Article
- Postpartum adversity in rats creates a hypervigilant maternal state through selective salience-circuit recruitment.Neurobiology of stress · 2026Article
- Attachment Theory: Novel Clinical and Molecular Insights.Biomolecules · 2026Review
- Social circuits under developmental threat: Bridging rodent and human neuroscience.Developmental review : DR · 2025Article
- Erratic Maternal Care Induces Avoidant-Like Attachment Deficits in a Mouse Model of Early Life Adversity.eNeuro · 2025Article
- Building a social brain: Cells, circuits and behavior across the lifespan.Neurobiology of stress · 2025Review
- Secure attachment to caregiver prevents adult depressive symptoms in a sex-dependent manner: A translational study.iScience · 2024Article
- Effects of Early Life Scarcity-Adversity on Maturational Milestones in Male and Female Rats.Developmental psychobiology · 2024Article
- The lateral habenula integrates age and experience to promote social transitions in developing rats.Cell reports · 2024Article
- The lateral habenula integrates age and experience to promote social transitions in developing rats.bioRxiv : the preprint server for biology · 2024Article
- Amygdala circuit transitions supporting developmentally-appropriate social behavior.Neurobiology of learning and memory · 2023Review
- From circuits to behavior: Amygdala dysfunction in fragile X syndrome.Frontiers in integrative neuroscience · 2023Review
- Infant pain vs. pain with parental suppression: Immediate and enduring impact on brain, pain and affect.PloS one · 2023Article
- Infant Social Withdrawal Behavior: A Key for Adaptation in the Face of Relational Adversity.Frontiers in psychology · 2022Article
- Rodent models of early adversity: Impacts on developing social behavior circuitry and clinical implications.Frontiers in behavioral neuroscience · 2022Review
- The Neurobiology of Infant Attachment-Trauma and Disruption of Parent-Infant Interactions.Frontiers in behavioral neuroscience · 2022Review
- Neurobiology of Parental Regulation of the Infant and Its Disruption by Trauma Within Attachment.Frontiers in behavioral neuroscience · 2022Review
- Bidirectional control of infant rat social behavior via dopaminergic innervation of the basolateral amygdala.Neuron · 2021Article
- Early life adversity affecting the attachment bond alters ventral tegmental area transcriptomic patterning and behavior almost exclusively in female mice.Neurobiology of stress · 2021Article
- Caregiving Influences on Development: A Sensitive Period for Biological Embedding of Predictability and Safety Cues.Current directions in psychological science · 2021Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
The roots of psychopathology frequently take shape during infancy in the context of parent-infant interactions and adversity. Yet, neurobiological mechanisms linking these processes during infancy remain elusive. Here, using responses to attachment figures among infants who experienced adversity as a benchmark, we assessed rat pup cortical local field potentials (LFPs) and behaviors exposed to adversity in response to maternal rough and nurturing handling by examining its impact on pup separation-reunion with the mother. We show that during adversity, pup cortical LFP dynamic range decreased during nurturing maternal behaviors, but was minimally impacted by rough handling. During reunion, adversity-experiencing pups showed aberrant interactions with mother and blunted cortical LFP. Blocking pup stress hormone during either adversity or reunion restored typical behavior, LFP power, and cross-frequency coupling. This translational approach suggests adversity-rearing produces a stress-induced aberrant neurobehavioral processing of the mother, which can be used as an early biomarker of later-life pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.