Evidence map›Paper›PMID 32111796›Full record

ArticleIn vivo (Athens, Greece)

The Role of Neutrophil-to-lymphocyte Ratio on the Effect of CRT for Patients With Rectal Cancer.

Daichi Ishikawa, Masaaki Nishi, Chie Takasu, Hideya Kashihara, Takuya Tokunaga, Jun Higashijima, Kozo Yoshikawa, Mitsuo Shimada

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Daichi IshikawaDepartment of Surgery, The University of Tokushima, Tokushima, Japan daichi-19850125@hotmail.co.jp.
Masaaki NishiDepartment of Surgery, The University of Tokushima, Tokushima, Japan.
Chie TakasuDepartment of Surgery, The University of Tokushima, Tokushima, Japan.
Hideya KashiharaDepartment of Surgery, The University of Tokushima, Tokushima, Japan.
Takuya TokunagaDepartment of Surgery, The University of Tokushima, Tokushima, Japan.
Jun HigashijimaDepartment of Surgery, The University of Tokushima, Tokushima, Japan.
Kozo YoshikawaDepartment of Surgery, The University of Tokushima, Tokushima, Japan.
Mitsuo ShimadaDepartment of Surgery, The University of Tokushima, Tokushima, Japan.
Tokushima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimNeutrophil-to-lymphocyte ratio (NLR) is an indicator of systemic inflammation and could be a predictive factor in malignant tumors. The aim of this study was to investigate the impact of NLR in patients with lower rectal cancer who received preoperative chemo-radiotherapy (CRT). PATIENTS AND

methodsForty-eight patients with lower rectal cancer who underwent preoperative CRT and curative resection were enrolled. Blood samples were obtained before and after CRT. The relationship of NLR with clinical outcome was investigated.

resultsPost-CRT NLR was higher compared to pre-CRT NLR. The patients with higher post-CRT NLR tended to have worse pathological response to CRT compared to those with low post-CRT NLR. The patients with high post-CRT NLR showed poorer 5-year overall survival and 3-year disease free survival while there was no correlation according to pre-CRT NLR. The univariate analysis showed that post-CRT stage and post-CRT NLR were associated with a poorer 5-year overall survival.

conclusionNLR after preoperative CRT could be a potential prognostic indicator for patients with lower rectal cancer.

Indexed as

ChemoradiotherapyLeukocyte CountLymphocytesNeutrophilsPreoperative CareAgedAged, 80 and overBiomarkers, TumorCombined Modality TherapyFemaleHumansMaleMiddle AgedNeoplasm StagingPrognosisRectal NeoplasmsBiomarkers, Tumorneutrophil-to-lymphocyte ratioNLRpreoperative chemoradiotherapyRectal cancer

Identifiers

PMID32111796
PMCPMC7157857
OpenAlexW3007918204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.