Evidence map›Paper›PMID 32111696›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Direct Interaction of PP2A Phosphatase with GABA

Xiaofan Li, Miho Terunuma, Tarek G Deeb, Shari Wiseman, Menelas N Pangalos, Angus C Nairn, Stephen J Moss, Paul A Slesinger

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. GABAeNeuro · 2026
    Article
  2. Article
  3. GABAFrontiers in pharmacology · 2026
    Review
  4. GABAMedComm · 2025
    Review
  5. Article
  6. Ethanol blocks a novel form of iLTD, but not iLTP of inhibitory inputs to VTA GABA neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  7. The CaMKII-dependent phosphorylation of GABACNS neuroscience & therapeutics · 2023
    Article
  8. Article
  9. Neuronal G protein-gated KAmerican journal of physiology. Cell physiology · 2022
    Review
  10. Protein phosphatase 2A regulation of GABAFrontiers in molecular neuroscience · 2022
    Article
  11. Expression and Function of GABA Receptors in Myelinating Cells.Frontiers in cellular neuroscience · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Xiaofan LiNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Miho TerunumaDivision of Oral Biochemistry, Graduate School of Medical and Dental Sciences, Niigata University, 951-8514 Japan.
Tarek G DeebDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111.ORCID 0000-0002-8989-7349
Shari WisemanDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111.
Menelas N PangalosIMED Biotech Unit, AstraZeneca, Cambridge, CB4 0WG United Kingdom, and.
Angus C NairnDepartment Psychiatry, Yale University School of Medicine, New Haven, Connecticut 065019.ORCID 0000-0002-7075-0195
Stephen J MossDepartment of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, paul.slesinger@mssm.edu stephen.moss@tufts.edu.
Paul A SlesingerNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York 10029, paul.slesinger@mssm.edu stephen.moss@tufts.edu.ORCID 0000-0002-3868-7528
Tufts University · USIcahn School of Medicine at Mount Sinai · USAstraZeneca (United Kingdom) · GBNiigata University · JPYale University · US

Funding

Yale/NIDA Neuroproteomics Research CenterP30DA018343 · NIDA · YALE UNIVERSITY · PI ANGUS C. NAIRN, Kenneth Robert WILLIAMS · 2004 to 2026
$37.1M
Structural Analysis of Alcohol-dependent Activation of GIRKsR01AA018734 · NIAAA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Paul A Slesinger · 2010 to 2026
$6.6M
Mechanisms that determine Glutamine synthetase activity in the brainR01NS081986 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2012 to 2022
$3.7M
Constructing inhibitory synapsesR01NS051195 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MOSS, STEPHEN J · 2006 to 2014
$3.2M
Studies on the structure of gamma-aminobutyric acid type A receptor subtypesR01MH118263 · NIMH · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2019 to 2023
$2.4M
Modulation of KCC2 activity and the postnatal development of synaptic inhibitionR01NS101888 · NINDS · TUFTS UNIVERSITY BOSTON · PI DEEB, TAREK ZIAD, MOSS, STEPHEN J · 2017 to 2021
$2.3M
Dissecting Mechanisms of GABAB-GIRK Plasticity with PsychostimulantsR01DA037170 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MOSS, STEPHEN J, SLESINGER, PAUL A · 2014 to 2018
$2.1M
Novel actions of neurosteroids on GABA (A) receptor traffickingR01MH097446 · NIMH · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW, MOSS, STEPHEN J · 2013 to 2017
$2.1M
Novel actions of neurosteroids on GABA (A) receptor traffickingR01NS108378 · NINDS · TUFTS UNIVERSITY BOSTON · PI DAVIES, PAUL ANDREW, MOSS, STEPHEN J · 2018 to 2022
$2.0M
Deficits in KCC2 activity and the pathophysiology of Status EpilepticusR01NS087662 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2014 to 2018
$2.0M
The role of ubiquitination in regulating GABA(A) receptor functional expressionR01NS056359 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MOSS, STEPHEN J · 2007 to 2010
$1.4M
Impaired KCC2 function underlies pharmacoresistant seizuresR21NS080064 · NINDS · TUFTS UNIVERSITY BOSTON · PI MOSS, STEPHEN J · 2013 to 2014
$452k
NIAAA NIH HHS R01 AA018734NIDA NIH HHS P30 DA018343NIDA NIH HHS R01 DA037170NIMH NIH HHS R01 MH097446NIMH NIH HHS R01 MH118263NINDS NIH HHS R01 NS051195NINDS NIH HHS R01 NS056359NINDS NIH HHS R01 NS081986NINDS NIH HHS R01 NS087662NINDS NIH HHS R01 NS101888NINDS NIH HHS R21 NS080064
6 · The paper itself

Abstract

Addictive drugs usurp the brain's intrinsic mechanism for reward, leading to compulsive and destructive behaviors. In the ventral tegmental area (VTA), the center of the brain's reward circuit, GABAergic neurons control the excitability of dopamine (DA) projection neurons and are the site of initial psychostimulant-dependent changes in signaling. Previous work established that cocaine/methamphetamine exposure increases protein phosphatase 2A (PP2A) activity, which dephosphorylates the GABA

Indexed as

AnimalsBrainFemaleG Protein-Coupled Inwardly-Rectifying Potassium ChannelsHEK293 CellsHumansMaleMiceMice, Inbred C57BLNeuronsPhosphorylationProtein Phosphatase 2RatsReceptors, GABA-BSignal TransductionSynaptic TransmissionG Protein-Coupled Inwardly-Rectifying Potassium ChannelsProtein Phosphatase 2Receptors, GABA-BGABA(B)GIRKinhibitionphosphatasePLAtrafficking

Identifiers

PMID32111696
PMCPMC7117905
OpenAlexW3006809188

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.