Evidence map›Paper›PMID 32111637›Full record

SynthesisJournal of neurology, neurosurgery, and psychiatry2020

Outcome measurement in functional neurological disorder: a systematic review and recommendations.

Susannah Pick, David G Anderson, Ali A Asadi-Pooya, Selma Aybek, Gaston Baslet, Bastiaan R Bloem, Abigail Bradley-Westguard, Richard J Brown, Alan J Carson, Trudie Chalder and 36 more

2 registry-linked trialsOpen access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in Journal of neurology, neurosurgery, and psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 62 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06422819 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Probing the Heart Rate Variability Biofeedback as an Innovative and Non-invasive Treatment for Functional Neurological Disorders Guided by a Multimodal Approach of Autonomic Nervous System.

TypeinterventionalSponsorCentre hospitalier de l'Université de Montréal (CHUM)Ran2024 to 2027Enrolled31ConditionsFunctional Neurological DisorderArmsHeart rate variability Biofeedback [HRV-BFB], Pseudo HRV-BFB
NCT07527403 recruitingnot on this mapstarted 2026, after this paper: background citation

Impact of Theta Burst Repetitive Transcranial Magnetic Stimulation on the Patient's Self-reported Improvement in Their Motor Functional Neurological Disorder

TypeobservationalSponsorHospital Center Guillaume RégnierRan2026 to 2028Enrolled22ConditionsFunctional Neurological Disorder, Motor FNDArmstheta-burst rTMS (repetitive transcranial magnetic stimulation)
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 1 synthesis or guideline pooled it, 150 citations in OpenAlex.

  1. Pooled it
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  7. Review
  8. Unmet needs in functional neurological disorder related to digital healthcare.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  9. Neurofeedback for functional neurological disorders: future directions for research and clinical practice.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  10. Treatment of Functional Neurological Disorders.Journal of clinical neurology (Seoul, Korea) · 2026
    Review
  11. Article
  12. Article
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors at 20 institutions in 13 countries.

Susannah PickInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0003-2001-6723
David G AndersonDonald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South Africa.
Ali A Asadi-PooyaEpilepsy Research Center, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of.ORCID 0000-0002-2598-7601
Selma AybekDepartment of Neurology, University Hospital Bern & University of Bern, Bern, Switzerland.ORCID 0000-0002-7877-6760
Gaston BasletDepartment of Psychiatry, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Bastiaan R BloemDepartment of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands.ORCID 0000-0002-6371-3337
Abigail Bradley-Westguard
Richard J BrownSchool of Health Sciences, The University of Manchester, Manchester, UK.ORCID 0000-0003-3961-2023
Alan J CarsonDepartment of Clinical Neurosciences, School of Molecular and Clinical Medicine, Western General Hospital, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-7425-0964
Trudie ChalderInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0003-0775-1045
Maria DamianovaDonald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South Africa.
Anthony S DavidInstitute of Mental Health, Division of Psychiatry, Faculty of Brain Sciences, University College London, London, United Kingdom.ORCID 0000-0003-0967-774X
Mark J EdwardsNeuroscience Research Centre, Institute of Molecular and Clinical Sciences, St George's University, London, UK.ORCID 0000-0002-8283-9015
Steven A EpsteinDepartment of Psychiatry, Georgetown University, Washington, District of Columbia, USA.
Alberto J EspayGardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA.ORCID 0000-0002-3389-136X
Béatrice GarcinDepartment of Neurology, Hopital Avicenne, Assistance Publique, Hôpitaux de Paris, Paris, Île-de-France, France.ORCID 0000-0001-9109-9904
Laura H GoldsteinInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0001-9387-3035
Mark HallettHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.ORCID 0000-0002-3180-6811
Joseph JankovicParkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0003-4129-3674
Eileen M JoyceUniversity College London Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK.ORCID 0000-0003-0469-2844
Richard A KanaanDepartment of Psychiatry, Austin Health, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0003-0992-1917
Roxanne C KeynejadInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0003-4434-3526
Kasia KozlowskaDiscipline of Psychiatry and Child and Adolescent Health, The Children's Hospital at Westmead, Sydney Medical School, Sydney, New South Wales, Australia.ORCID 0000-0002-9578-0753
Kathrin LaFaverDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0001-5416-894X
W Curt LaFranceDepartments of Psychiatry and Neurology, Rhode Island Hospital, Brown Medical School, Providence, RI, USA.ORCID 0000-0002-4901-3852
Anthony E LangMovement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0003-1229-3667
Alex LehnMater Neurosciences Centre, Brisbane, Queensland, Australia.ORCID 0000-0003-2780-6496
Sarah LidstoneMovement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0002-0147-0202
Carine W MaurerDepartment of Neurology, Stony Brook University Renaissance School of Medicine, Stony Brook, New York, USA.ORCID 0000-0002-7892-7127
Bridget MildonFND Hope International, Salmon, Idaho, USA.ORCID 0000-0001-7191-3163
Francesca MorganteNeuroscience Research Centre, Institute of Molecular and Clinical Sciences, St George's University, London, UK.ORCID 0000-0002-9834-3639
Lorna MyersNortheast Regional Epilepsy Group, New York, New York, USA.ORCID 0000-0001-7706-9952
Clare NicholsonTherapy Services, The National Hospital for Neurology and Neurosurgery, London, UK.ORCID 0000-0002-8047-6820
Glenn NielsenNeuroscience Research Centre, Institute of Molecular and Clinical Sciences, St George's University, London, UK.ORCID 0000-0001-6053-5670
David L PerezDepartments of Neurology and Psychiatry, Therapy Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.ORCID 0000-0003-2721-583X
Stoyan PopkirovDepartment of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, Bochum, Germany.ORCID 0000-0001-6168-0036
Markus ReuberAcademic Neurology Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK.ORCID 0000-0002-4104-6705
Karen S RommelfangerDepartments of Neurology and Psychiatry and Behavioral Sciences, Emory Centre for Ethics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-2667-1190
Petra SchwingenshuhDepartment of Neurology, Medical University of Graz, Graz, Austria.ORCID 0000-0002-3294-6824
Tereza SerranovaDepartment of Neurology and Center of Clinical Neuroscience, Charles University in Prague, Prague, Czech Republic.ORCID 0000-0001-6525-3971
Paul ShotboltInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0001-8868-837X
Glenn T StebbinsDepartment of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.ORCID 0000-0001-7905-9336
Jon StoneDepartment of Clinical Neurosciences, School of Molecular and Clinical Medicine, Western General Hospital, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-9829-8092
Marina Aj TijssenDepartment of Neurology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.ORCID 0000-0001-5783-571X
Michele TinazziDepartment of Neuroscience, Biomedicine, and Movement, University of Verona, Verona, Italy.ORCID 0000-0002-2370-7063
Timothy R NicholsonInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK timothy.nicholson@kcl.ac.uk.ORCID 0000-0002-2350-2332
King's College London · GBSt George's, University of London · GBNational Hospital for Neurology and Neurosurgery · GBUniversity Health Network · CAUniversity of the Witwatersrand · ZAWestern General Hospital · GBAssistance Publique – Hôpitaux de Paris · FRBaylor College of Medicine · USBrigham and Women's Hospital · USCharles University · CZChildren's Hospital at Westmead · AUEmory University · USGeorgetown University · USHarvard University · USInstitute of Mental Health · GBManchester Academic Health Science Centre · GBMater Health Services · AUMedical University of Graz · ATNational Institute of Neurological Disorders and Stroke · USNorthEast Regional Epilepsy Group · US

Funding

Pathophysiology of Involuntary Movements and Volitional DisordersZIANS002667 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI HALLETT, MARK · 2009 to 2023
$17.7M
Treatments for Psychogenic Nonepileptic Seizures (NES)K23NS045902 · NINDS · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI LAFRANCE, W CURT · 2003 to 2007
$818k
Department of Health CS-2014-14-016NINDS NIH HHS K23 NS045902
6 · The paper itself

Abstract

objectivesWe aimed to identify existing outcome measures for functional neurological disorder (FND), to inform the development of recommendations and to guide future research on FND outcomes.

methodsA systematic review was conducted to identify existing FND-specific outcome measures and the most common measurement domains and measures in previous treatment studies. Searches of Embase, MEDLINE and PsycINFO were conducted between January 1965 and June 2019. The findings were discussed during two international meetings of the FND-Core Outcome Measures group.

resultsFive FND-specific measures were identified-three clinician-rated and two patient-rated-but their measurement properties have not been rigorously evaluated. No single measure was identified for use across the range of FND symptoms in adults. Across randomised controlled trials (k=40) and observational treatment studies (k=40), outcome measures most often assessed core FND symptom change. Other domains measured commonly were additional physical and psychological symptoms, life impact (ie, quality of life, disability and general functioning) and health economics/cost-utility (eg, healthcare resource use and quality-adjusted life years).

conclusionsThere are few well-validated FND-specific outcome measures. Thus, at present, we recommend that existing outcome measures, known to be reliable, valid and responsive in FND or closely related populations, are used to capture key outcome domains. Increased consistency in outcome measurement will facilitate comparison of treatment effects across FND symptom types and treatment modalities. Future work needs to more rigorously validate outcome measures used in this population.

Indexed as

Outcome Assessment, Health CareHumansNervous System Diseasesclinical neurologyconversion disorderfunctional neurological disordermovement disordersneuropsychiatry

Identifiers

PMID32111637
PMCPMC7279198
OpenAlexW2997432804

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.