ArticleMolecular and cellular biology1988
Expression of heat shock proteins by isolated mouse spermatogenic cells.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 96 citations in OpenAlex.
- Beyond swimming: emerging parameters for predicting the fertility of mouse spermatozoa.Lab animal · 2025Review
- Implications of sperm heat shock protein 70-2 in bull fertility.Veterinary world · 2022Review
- Dynamics of HSPA1A and redox status in the spermatozoa and fluid from different segments of goat epididymis.Cell stress & chaperones · 2020Article
- What's Genetic Variation Got to Do with It? Starvation-Induced Self-Fertilization Enhances Survival in Paramecium.Genome biology and evolution · 2020Article
- Aberrant Expression of Dynein light chain 1 (DYNLT1) is Associated with Human Male Factor Infertility.Molecular & cellular proteomics : MCP · 2015Article
- Malfunction of spermatogenesis in experimental ischemic mice.The Journal of reproduction and development · 2015Article
- Reporter mice express green fluorescent protein at initiation of meiosis in spermatocytes.Genesis (New York, N.Y. : 2000) · 2014Article
- Heat stress response of male germ cells.Cellular and molecular life sciences : CMLS · 2013Review
- Molecular cloning and characterization of cDNA encoding a putative stress-induced heat-shock protein from Camelus dromedarius.International journal of molecular sciences · 2011Article
- Development and application of a system for seminolipid metabolism using mouse seminiferous tubules.Glycoconjugate journal · 2010Article
- Heat shock proteins on the human sperm surface.Journal of reproductive immunology · 2010Article
- The expression pattern of the 70-kDa heat shock protein Hspa2 in mouse tissues.Histochemistry and cell biology · 2009Article
- Hsp70B' regulation and function.Cell stress & chaperones · 2007Article
- Hsp70B' regulation and function.Cell stress & chaperones · 2007Article
- Expression of Hsp70-2 in unilateral cryptorchid testis of rhesus monkey during germ cell apoptosis.Endocrine · 2001Article
- Heat shock protein expression during gametogenesis and embryogenesis.Infectious diseases in obstetrics and gynecology · 1999Review
- Stress proteins in reproductive toxicology.Environmental health perspectives · 1997Article
- Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Article
- Testis-specific mak protein kinase is expressed specifically in the meiotic phase in spermatogenesis and is associated with a 210-kilodalton cellular phosphoprotein.Molecular and cellular biology · 1993Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteins of the hsp70 family are abundant in mouse spermatogenic cells. These cells also synthesize relatively large amounts of a 70,000-molecular-weight protein (P70) that appears to be a cell-specific isoform of hsp70, the major heat-inducible protein (R.L. Allen, D.A. O'Brien, and E.M. Eddy, Mol. Cell. Biol. 8:828-832, 1988). In this study, proteins of unstressed and heat-stressed spermatogenic cells consisting of purified preparations of preleptotene, leptotene-zygotene, pachytene spermatocytes, and round spermatids were analyzed by two-dimensional polyacrylamide gel electrophoresis. Unstressed preleptotene and leptotene-zygotene spermatocytes contained little P70, whereas relatively large amounts of P70 were present in pachytene spermatocytes and round spermatids. Labeling studies showed that P70 was synthesized primarily in pachytene spermatocytes and that little synthesis occurred in round spermatids or in preleptotene and leptotene-zygotene stages of spermatogenesis. Synthesis of hsp70 was not detectable in unstressed cells but was induced in all stages of isolated germ cells following heat stress. These results indicate that P70 is expressed in a stage-specific manner during cell differentiation, whereas hsp70 is synthesized in response to stress in all populations of isolated spermatogenic cells examined.
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