Evidence map›Paper›PMID 32111324›Full record

ArticlePoultry science2020

Preliminary evaluation of application of a 3-dimensional network structure of siloxanes Dergall preparation on chick embryo development and microbiological status of eggshells.

Michał Patrzałek, Maja Kosecka-Strojek, Klaudia Lisowska-Łysiak, Magdalena Trela, Mariusz Kot, Magdalena Gawlak, Dawid Liszka, Mieczysław Sajewicz, Barbara Tombarkiewicz, Krzysztof Pawlak and 2 more

Abstract read
In one paragraph

Article in Poultry science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Pathogens (Basel, Switzerland) · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michał PatrzałekDepartment of Research and Development, ICB Pharma Jaworzno, Jaworzno 43-603, Poland.
Maja Kosecka-StrojekDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Krakow, Krakow 30-387, Poland.
Klaudia Lisowska-ŁysiakDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Krakow, Krakow 30-387, Poland.
Magdalena TrelaDepartment of Zoology and Animal Welfare, University of Agriculture in Krakow, Krakow 30-054, Poland.
Mariusz KotDepartment of Research and Development, ICB Pharma Jaworzno, Jaworzno 43-603, Poland.
Magdalena GawlakThe Institute of Plant Protection - National Research Institute, The Research Centre of Quarantine, Invasive and Genetically Modified Organisms, Poznan 60-318, Poland.
Dawid LiszkaDepartment of Research and Development, ICB Pharma Jaworzno, Jaworzno 43-603, Poland.
Mieczysław SajewiczDepartment of General Chemistry and Chromatography, University of Silesia in Katowice, Katowice 40-007, Poland.
Barbara TombarkiewiczDepartment of Zoology and Animal Welfare, University of Agriculture in Krakow, Krakow 30-054, Poland.
Krzysztof PawlakDepartment of Zoology and Animal Welfare, University of Agriculture in Krakow, Krakow 30-054, Poland.
Jacek MiędzobrodzkiDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Krakow, Krakow 30-387, Poland.
Marcin W LisDepartment of Zoology and Animal Welfare, University of Agriculture in Krakow, Krakow 30-054, Poland. Electronic address: rzlis@cyf-kr.edu.pl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The spatial network structure of Dergall is based on substances nontoxic to humans and the environment which, when applied on solid surfaces, creates a coating that reduces bacterial cell adhesion. The bacteriostatic properties of siloxanes are based on a purely physical action mechanism which excludes development of drug-resistant microorganisms. The aims of the present study were to 1) evaluate a Dergall layer formed on the eggshell surface regarding the potential harmful effects on the chick embryo; 2) evaluate antimicrobial activity and estimate the prolongation time of Dergall's potential antimicrobial activity. Dergall at a concentration of 0.6% formed a layer on the eggshell surface. In vitro testing of the potential harmful effects of Dergall by means of a hen embryo test of the chorioallantoic membrane showed no irritation reaction at a concentration of 3% and lower. The hatchability of the groups sprayed with a Dergall water solution with a concentration of 0 to 5% was 89.1 to 93.8% for fertilized eggs (P > 0.05) but decreased to 63.7% (P < 0.05) in the group sprayed with a 6% concentration of the solution. This phenomenon was caused by embryo mortality in the first week of incubation. At the concentration of 0.6%, Dergall exhibited strong antibacterial properties against bacteria such as Staphylococcus aureus, Escherichia coli, Shigella dysenteriae, Shigella flexneri, and Salmonella typhimurium. For Streptococcus pyogenes, the highest antibacterial activity of Dergall was reported in the concentrations of 100 and 50%. For Pseudomonas aeruginosa, no antibacterial activity of Dergall was generally observed, but in vivo testing showed a strong decrease of all gram-negative bacteria growth. Moreover, a prolonged antimicrobial effect lasting until 3 D after disinfection was observed, which makes Dergall a safe and efficient disinfectant.

Indexed as

AnimalsAnti-Bacterial AgentsBacteriaBacterial Physiological PhenomenaChick EmbryoChickensDose-Response Relationship, DrugEgg ShellSiloxanesAnti-Bacterial AgentsSiloxanesantibacterial effectchickenHET-CAMsilicon

Identifiers

PMID32111324
PMCPMC7587672

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.