ArticlePoultry science2020
Effects of Eimeria tenella infection on the barrier damage and microbiota diversity of chicken cecum.
Article in Poultry science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- The global prevalence and associated risk factors of Eimeria infection in domestic chickens: A systematic review and meta-analysis.Veterinary medicine and science · 2024Pooled it
- Identification and Characterization ofMicroorganisms · 2026Article
- Effects of phytogenic feed additive on growth performance, gut health, and antioxidant capacity in broiler chickens challenged with pathogenic Eimeria tenella.Poultry science · 2026Article
- Exploration of the efficacy of eucalyptus oil (micro-capsules) and mangosteen extract against Eimeria tenella infection in chickens.Poultry science · 2026Article
- Gentiana scabra mitigates Eimeria tenella-induced Coccidiosis by regulating the gut microbiota-metabolome and strengthening the intestinal barrier.Poultry science · 2026Article
- Short-Chain Fatty Acids Regulate Poultry Feed Intake via the Hypothalamus: Receptor-Mediated and Epigenetic Mechanisms.Animals : an open access journal from MDPI · 2026Review
- Metabolomic and Metagenomic Correlation Reveals the Network Regulatory Mechanism of Cecal Microbiota Structural Changes Induced byInternational journal of veterinary science and medicine · 2026Article
- Comparison of Gut Microbiome Profile of Chickens Infected with ThreeMicroorganisms · 2025Article
- Metagenomic Insight into Cecal Microbiota Shifts in Broiler Chicks FollowingMicroorganisms · 2025Article
- Evaluating Good Husbandry Practices and Organic Fermented Additives for Coccidiosis Control in a Pilot Study Using Slow-Growing Broilers.Animals : an open access journal from MDPI · 2025Article
- Metagenomic Analysis Reveals the Characteristics of Cecal Microbiota in Chickens with Different Levels of Resistance During Recovery fromAnimals : an open access journal from MDPI · 2025Article
- Single-cell transcriptomic atlas of the chicken cecum reveals cellular responses and state shifts during Eimeria tenella infection.BMC genomics · 2025Article
- Molecular epidemiology ofMicrobial genomics · 2025Article
- Coccidia Vaccine Challenge and Exogenous Enzyme Supplementation in Broiler Chicken 2-Effect on Apparent Ileal Nutrient and Energy Digestibility and Intestinal Morphology 7 and 14 Days Post-Challenge.Animals : an open access journal from MDPI · 2025Article
- Temporal changes in cecal luminal and mucosal microbiota of broiler chickens with clinical coccidiosis (Eimeria maxima).PloS one · 2025Article
- Investigation of Intestinal Health in Broiler Chickens FollowingThe journal of poultry science · 2025Article
- Alterations in Ileal Microbiota and Fecal Metabolite Profiles of Chickens with Immunity toAnimals : an open access journal from MDPI · 2024Article
- Eimeria: Navigating complex intestinal ecosystems.PLoS pathogens · 2024Review
- Alteration in the Gut Microbiota of Chickens Resistant toMicroorganisms · 2024Article
- Temporal Changes in Jejunal and Ileal Microbiota of Broiler Chickens with Clinical Coccidiosis (Animals : an open access journal from MDPI · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The symbiosis of host and intestinal microbiota constitutes a microecosystem and plays an important role in maintaining intestinal homeostasis and regulating the host's immune system. Eimeria tenella, an obligate intracellular apicomplexan parasite, can cause coccidiosis, a serious intestinal disease. In this study, the effects of E. tenella infection on development parameters (villus height, crypt depth, mucosa thickness, muscularis thickness, and serosa thickness) and microbiota in chicken cecum were investigated. Fourteen-day-old male Hy-Line Variety Brown layer chickens were inoculated with sporulated oocysts of E. tenella. Cecal tissues were collected 7 d after inoculation. Relative density of goblet cells and glycoproteins were determined by Alcian blue periodic acid-Schiff staining and periodic acid-Schiff staining, respectively. Intestinal development parameters were also evaluated. Cecal contents were extracted, and the composition of cecal microflora was examined by Illumine sequencing in the V3-V4 region of the 16S rRNA gene. Results indicated that E. tenella infection destroyed the structure of cecal tissue and reduced the relative density of goblet cells and glycoproteins. Sequencing analysis indicated that E. tenella infection altered the diversity and composition of cecal microbiota. The populations of Proteobacteria, Enterococcus, Incertae, and Escherichia-Shigella decreased, and those of Bacteroidales and Rikenella significantly increased in the infected group compared with those in the control group. Hence, the pathological damage caused by E. tenella infection is associated with cecal microbiota dysbiosis, and this finding may be used to develop an alternative measure for alleviating the effect of coccidiosis on the poultry industry.
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