ArticleMolecular and cellular biology1988
Tandemly repeated exons encode 81-base repeats in multiple, developmentally regulated Schistosoma mansoni transcripts.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- RevisitingBiomolecules · 2023Article
- Increased efficiency of evolved group I intron spliceozymes by decreased side product formation.RNA (New York, N.Y.) · 2015Article
- Sm10.3, a member of the micro-exon gene 4 (MEG-4) family, induces erythrocyte agglutination in vitro and partially protects vaccinated mice against Schistosoma mansoni infection.PLoS neglected tropical diseases · 2014Article
- The role played by alternative splicing in antigenic variability in human endo-parasites.Parasites & vectors · 2014Review
- The schistosome oesophageal gland: initiator of blood processing.PLoS neglected tropical diseases · 2013Article
- Protein variation in blood-dwelling schistosome worms generated by differential splicing of micro-exon gene transcripts.Genome research · 2010Article
- Immune effector mechanisms against schistosomiasis: looking for a chink in the parasite's armour.Trends in parasitology · 2009Review
- Comparison of 18S ribosomal RNA gene sequences of Eurytrema coelmaticum and Eurytrema pancreaticum.Parasitology research · 2007Article
- A spliced leader is present on a subset of mRNAs from the human parasite Schistosoma mansoni.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Molecular cloning and sequence analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase from the human parasite Schistosoma mansoni.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Organization and expression of 5S rRNA genes in the parasitic nematode, Brugia malayi.Nucleic acids research · 1989Article
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5 authors.
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Abstract
The adult Schistosoma mansoni cDNA clone 10-3 encodes an antigen that is recognized by sera from infected humans. We characterized multiple developmentally regulated transcripts homologous to the 10-3 cDNA and portions of the complex genomic loci encoding those transcripts. Transcripts of approximately 950, 870, and 780 nucleotides were expressed in adults, whereas only the 780-nucleotide transcript was observed in the larval stage. These transcripts were highly similar, containing variable numbers of identical direct tandem repeats of 81 bases. Although the sequence of the repeating elements and sequences 3' to them were identical in all the transcripts, sequences 5' of the repeating elements exhibited variations, including a 27-base insertion, alternative start sites for transcription, and alternate 5' exon usage. These transcripts appeared to be derived in part by the developmentally controlled alternative splicing of small exons and the use of alternative transcription initiation sites from the one or two complex loci of at least 40 kilobase pairs. Each 81-base repeat in the transcripts was encoded by three dispersed 27-base-pair exons. These 27-base-pair exons were contained within highly conserved, reiterated 3-kilobase-pair genomic tandem arrays.
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