Evidence map›Paper›PMID 32111134›Full record

Observational studyJournal of neurotrauma2020

Anti-Pituitary and Anti-Hypothalamus Autoantibody Associations with Inflammation and Persistent Hypogonadotropic Hypogonadism in Men with Traumatic Brain Injury.

Sushupta M Vijapur, Zhihui Yang, David J Barton, Leah Vaughan, Nabil Awan, Raj G Kumar, Byung-Mo Oh, Sarah L Berga, Kevin K Wang, Amy K Wagner

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of neurotrauma, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Neuroendocrine Disruptions Following Head Injury.Current neurology and neuroscience reports · 2023
    Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Sushupta M VijapurDepartment of Physical Medicine & Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Zhihui YangBrain Rehabilitation Research Center, Malcom Randall VA Medical Center, North Florida / South Georgia Veterans Health System, Gainesville, Florida, USA.
David J BartonDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Leah VaughanDepartment of Physical Medicine & Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Nabil AwanDepartment of Physical Medicine & Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Raj G KumarMount Sinai, Icahn School of Medicine, New York, New York, USA.
Byung-Mo OhDepartment of Rehabilitation Medicine, Seoul National University, Seoul, South Korea.
Sarah L BergaDepartment of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA.
Kevin K WangDepartment of Emergency Medicine, Psychiatry and Neuroscience, University of Florida, Gainesville, Florida, USA.
Amy K WagnerDepartment of Physical Medicine & Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
University of Pittsburgh · USUniversity of Florida · USIcahn School of Medicine at Mount Sinai · USSeoul National University · KRUniversity of Utah · US

Funding

Elucidate Consequences of Autoimmune Response to Protease-modified GFAP in TBIR21NS085455 · NINDS · UNIVERSITY OF FLORIDA · PI WANG, KEVIN KA WANG · 2014 to 2015
$397k
NINDS NIH HHS R21 NS085455
6 · The paper itself

Abstract

Traumatic brain injury (TBI) and can lead to persistent hypogonadotropic hypogonadism (PHH) and poor outcomes. We hypothesized that autoimmune and inflammatory mechanisms contribute to PHH pathogenesis. Men with moderate-to-severe TBI (

Indexed as

AdolescentAdultAgedAutoantibodiesAutoimmunityBrain Injuries, TraumaticCohort StudiesHumansHypogonadismHypothalamusInflammationInflammation MediatorsLongitudinal StudiesMaleMiddle AgedPituitary GlandAutoantibodiesInflammation MediatorsautoantibodiesautoimmunityhypogonadismhypopituitarismIgG autoantibodyIgM autoantibodyinflammationTBI

Identifiers

PMID32111134
PMCPMC7336882
OpenAlexW3008622162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.