Evidence map›Paper›PMID 32110966›Full record

ArticleAntibiotics (Basel, Switzerland)2020

Synthesis and Bioactivity of Thiazolethioacetamides as Potential Metallo-β-Lactamase Inhibitors.

Yi-Lin Zhang, Yong Yan, Xue-Jun Wang, Ke-Wu Yang

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Approachable Synthetic Methodologies for Second-GenerationPharmaceuticals (Basel, Switzerland) · 2024
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yi-Lin ZhangCollege of Biology Pharmacy and Food Engineering, Shangluo University, Shangluo 726000, China.
Yong YanCollege of Biology Pharmacy and Food Engineering, Shangluo University, Shangluo 726000, China.
Xue-Jun WangCollege of Biology Pharmacy and Food Engineering, Shangluo University, Shangluo 726000, China.
Ke-Wu YangKey Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, China.

Funding

the Natural Science Foundation of Shaanxi Province 2018JQ2070the Natural Science Foundation of Shangluo University 16SKY021the science and technology development fund of Zhang Shengyong academician 18YSZX002the Scientific Research Plan Project by Educational Department of Shaanxi Province 18JK0250
6 · The paper itself

Abstract

Metallo-β-lactamase (MβLs) mediated antibiotic resistance seriously threatens the treatment of bacterial diseases. Recently, we found that thioacetamides can be a potential MβL inhibitor skeleton. In order to improve the information of the skeleton, twelve new thiazolethioacetamides were designed by modifying the aromatic substituent. Biological activity assays identify the thiazolethioacetamides can inhibit ImiS with IC

Indexed as

inhibitormetallo-β-lactamasethiazolethioacetamides

Identifiers

PMID32110966
PMCPMC7175138

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.