ArticleMaterials (Basel, Switzerland)2020
Biological Reactions to Metal Particles and Ions in the Synovial Layer of Mice.
Article in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Findings From 333 Retrieved MoM Total Hip Arthroplasty Components of a Single Design Reveal Modular Interface Corrosion as Most Common Feature.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Article
- Modification of low nickel biograde stainless steel with graphene oxide for enhanced corrosion resistance and in vivo biocompatibility.Scientific reports · 2025Article
- Combination of cobalt, chromium and titanium nanoparticles increases cytotoxicityJournal of orthopaedic translation · 2023Article
- The Expression Levels of Toll-like Receptors after Metallic Particle and Ion Exposition in the Synovium of a Murine Model.Journal of clinical medicine · 2021Article
- Special Issue "Novel Research about Biomechanics and Biomaterials Used in Hip, Knee and Related Joints".Materials (Basel, Switzerland) · 2021Article
- Bacterial Biofilm Components Induce an Enhanced Inflammatory Response Against Metal Wear Particles.Therapeutics and clinical risk management · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Metal particles and ions released from implants not only have a fundamental effect on the longevity of total joint replacements, but can also be disseminated to remote organs. Periprosthetic tissues harvested during revision surgeries mainly reflect end-stage failure but may not adequately reveal initial biological reactions and systemic side effects. Therefore, primary reactions caused by metal particles and ions were investigated in an established murine model. Left knee joints in three groups, each consisting of ten female BALB/c mice, received injections of metal ions (MI), metal particles (MP) and phosphate-buffered saline (PBS) (control). Seven days after the injection, immunohistochemical analyses of the synovial layer were performed with respect to some biological markers including Tumor necrosis factor -α (TNF-α), Interleukin-6 (IL-6), Interleukin-1β (IL-1β), Cluster of Differentiation 45 (CD45), Cluster of Differentiation 68 (CD68) and Cluster of Differentiation 3(CD3). The MP group showed significantly enhanced proinflammatory cytokine expression (TNF-α, IL-6 and IL-1β) compared with the other groups (p < 0.05). Interestingly, CD3, as a marker for T lymphocytes, did not increase in any of the groups. The MI group showed a significantly increased expression of CD45 compared with the control group (p < 0.05). Therefore, during the primary process, metal particles have stronger pro-inflammatory potential than metal ions, and T lymphocytes did not seem to be activated in our murine model. Systemic reactions caused by metal particles and ions were found by observing the untreated right knees.
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Registered trials
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