Evidence map›Paper›PMID 32110775›Full record

ArticleJournal of engineering and science in medical diagnostics and therapy2019

Toward Automation of the Supine Pressor Test for Preeclampsia.

Hamna J Qureshi, Jessica L Ma, Jennifer L Anderson, Brett M Bosinski, Aditi Acharya, Rachel D Bennett, David M Haas, Abigail D Cox, George R Wodicka, David G Reuter and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of engineering and science in medical diagnostics and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hamna J QureshiWeldon School of Biomedical Engineering, Purdue University, 206 South Martin Jischke Drive, West Lafayette, IN 47907.
Jessica L MaWeldon School of Biomedical Engineering, Purdue University, 206 South Martin Jischke Drive, West Lafayette, IN 47907.
Jennifer L AndersonWeldon School of Biomedical Engineering, Purdue University, 206 South Martin Jischke Drive, West Lafayette, IN 47907.
Brett M BosinskiSchool of Electrical and Computer Engineering, Purdue University, 465 Northwestern Avenue, West Lafayette, IN 47907.
Aditi AcharyaWeldon School of Biomedical Engineering, Purdue University, 206 South Martin Jischke Drive, West Lafayette, IN 47907.
Rachel D BennettSchool of Medicine, Indiana University, 550 North University Boulevard, Indianapolis, IN 46202.
David M HaasSchool of Medicine, Indiana University, 720 Eskenazi Avenue, Indianapolis, IN 46202.
Abigail D CoxCollege of Veterinary Medicine, Purdue University, 625 Harrison Street, West Lafayette, IN 47907.
George R WodickaWeldon School of Biomedical Engineering, Purdue University, 206 South Martin Jischke Drive, West Lafayette, IN 47907.
David G ReuterSeattle Children's Hospital, 1980 North Creek Parkway, Bothell, WA 98011.
Craig J GoergenWeldon School of Biomedical Engineering, Purdue Center for Cancer Research, Purdue University, 206 South Martin Jischke Drive, West Lafayette, IN 47907.
Purdue University West Lafayette · USIndiana University – Purdue University Indianapolis · USSeattle Children's Hospital · US

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Interdisciplinary Bioengineering Training in Diabetes ResearchT32DK101001 · NIDDK · PURDUE UNIVERSITY · PI EVANS-MOLINA, CARMELLA, VOYTIK-HARBIN, SHERRY L · 2013 to 2022
$1.6M
NCATS NIH HHS UL1 TR002529NIDDK NIH HHS T32 DK101001
6 · The paper itself

Abstract

Preeclampsia leads to increased risk of morbidity and mortality for both mother and fetus. Most previous studies have largely neglected mechanical compression of the left renal vein by the gravid uterus as a potential mechanism. In this study, we first used a murine model to investigate the pathophysiology of left renal vein constriction. The results indicate that prolonged renal vein stenosis after 14 days can cause renal necrosis and an increase in blood pressure (BP) of roughly 30 mmHg. The second part of this study aimed to automate a diagnostic tool, known as the supine pressor test (SPT), to enable pregnant women to assess their preeclampsia development risk. A positive SPT has been previously defined as an increase of at least 20 mmHg in diastolic BP when switching between left lateral recumbent and supine positions. The results from this study established a baseline BP increase between the two body positions in nonpregnant women and demonstrated the feasibility of an autonomous SPT in pregnant women. Our results demonstrate that there is a baseline increase in BP of roughly 10-14 mmHg and that pregnant women can autonomously perform the SPT. Overall, this work in both rodents and humans suggests that (1) stenosis of the left renal vein in mice leads to elevation in BP and acute renal failure, (2) nonpregnant women experience a baseline increase in BP when they shift from left lateral recumbent to supine position, and (3) the SPT can be automated and used autonomously.

Identifiers

PMID32110775
PMCPMC7045991
OpenAlexW2980405823

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.