Evidence map›Paper›PMID 32110368›Full record

ArticleChemical science2020

Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups.

Julian Tu, Dennis Svatunek, Saba Parvez, Hannah J Eckvahl, Minghao Xu, Randall T Peterson, K N Houk, Raphael M Franzini

Abstract read
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Crystal structures of products from the BBrActa crystallographica. Section E, Crystallographic communications · 2026
    Article
  2. Article
  3. Click-to-Release Reactions for Tertiary Amines and Pyridines.Journal of the American Chemical Society · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Click-Triggered Bioorthogonal Bond-Cleavage Reactions.Topics in current chemistry (Cham) · 2025
    Review
  8. Article
  9. Review
  10. Review
  11. Click chemistry and drug delivery: A bird's-eye view.Acta pharmaceutica Sinica. B · 2023
    Review
  12. Biosynthesis of Isonitrile- and Alkyne-Containing Natural Products.Annual review of chemical and biomolecular engineering · 2022
    Review
  13. Dynamic Nucleophilic Aromatic Substitution of Tetrazines.Angewandte Chemie (International ed. in English) · 2021
    Article
  14. Review
  15. Review
  16. Bioorthogonal chemistry.Nature reviews. Methods primers · 2021
    Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julian TuDepartment of Medicinal Chemistry , College of Pharmacy , University of Utah , Salt Lake City , 84112 , USA . Email: Raphael.franzini@utah.edu.ORCID 0000-0002-5645-8577
Dennis SvatunekDepartment of Chemistry and Biochemistry , University of California , Los Angeles , California 90095 , USA.ORCID 0000-0003-1101-2376
Saba ParvezDepartment of Pharmacology and Toxicology , College of Pharmacy , University of Utah , Salt Lake City , 84112 , USA.ORCID 0000-0001-8608-1494
Hannah J EckvahlDepartment of Chemistry and Biochemistry , University of California , Los Angeles , California 90095 , USA.ORCID 0000-0003-4224-4233
Minghao XuDepartment of Medicinal Chemistry , College of Pharmacy , University of Utah , Salt Lake City , 84112 , USA . Email: Raphael.franzini@utah.edu.ORCID 0000-0002-7684-4926
Randall T PetersonDepartment of Pharmacology and Toxicology , College of Pharmacy , University of Utah , Salt Lake City , 84112 , USA.
K N HoukDepartment of Chemistry and Biochemistry , University of California , Los Angeles , California 90095 , USA.ORCID 0000-0002-8387-5261
Raphael M FranziniDepartment of Medicinal Chemistry , College of Pharmacy , University of Utah , Salt Lake City , 84112 , USA . Email: Raphael.franzini@utah.edu.ORCID 0000-0001-6772-5119

Funding

Bioorthogonal CycloadditionsR01GM109078 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOUK, KENDALL N · 2015 to 2018
$1.1M
Austrian Science Fund FWF J 4216NIGMS NIH HHS R01 GM109078
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID32110368
PMCPMC7012038

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.