ArticleChemical science2019
Scale-up of microdroplet reactions by heated ultrasonic nebulization.
Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 75 citations in OpenAlex.
- Accelerated Chemistry in Microdroplets.Accounts of chemical research · 2026Article
- Early-stage drug discovery in a new-generation ultrahigh-throughput mass spectrometry platform.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Liquid Crystal-Driven Chemical Feeding Accelerates Condensation Reactions in Droplet Microreactors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Study on Microdroplets Generation and Detection Method in Four-Way Microfluid Structure (FWMS) by Double Photoresist Method Pulses.Micromachines · 2025Article
- Interfacial electromigration for accelerated reactions.Analytica chimica acta · 2025Article
- Detection of Retinoic Acid in Cosmetics Using Reactive Paper Spray Ionization Mass Spectrometry.Molecules (Basel, Switzerland) · 2025Article
- Rapid Exploration of Chemical Space by High-Throughput Desorption Electrospray Ionization Mass Spectrometry.Journal of the American Chemical Society · 2024Article
- Reaction acceleration at the surface of a levitated droplet by vapor dosing from a partner droplet.Chemical science · 2024Article
- Enhanced Compound Analysis Using Reactive Paper Spray Mass Spectrometry: Leveraging Schiff Base Reaction for Amino Acid Detection.Analytical chemistry · 2024Article
- Stereoselectivity in electrosprayed confined volumes: asymmetric synthesis of warfarin by diamine organocatalysts in microdroplets and thin films.RSC advances · 2024Article
- Review
- Accelerated and Concerted Aza-Michael Addition and SuFEx Reaction in Microdroplets in Unitary and High-Throughput Formats.Angewandte Chemie (International ed. in English) · 2022Article
- Spatial reorganization of analytes in charged aqueous microdroplets.Chemical science · 2022Article
- Simultaneous and Spontaneous Oxidation and Reduction in Microdroplets by the Water Radical Cation/Anion Pair.Angewandte Chemie (International ed. in English) · 2022Article
- Coupling of acceptor-substituted diazo compounds and tertiary thioamides: synthesis of enamino carbonyl compounds and their pharmacological evaluation.RSC advances · 2022Article
- A critical analysis of electrospray techniques for the determination of accelerated rates and mechanisms of chemical reactions in droplets.Chemical science · 2020Article
- Identifying reactive intermediates by mass spectrometry.Chemical science · 2020Review
- Molecular reactions at aqueous interfaces.Nature reviews. Chemistry · 2020Review
- Accelerated microdroplet synthesis of benzimidazoles by nucleophilic addition to protonated carboxylic acids.Chemical science · 2020Article
- Reaction of chloroauric acid with histidine in microdroplets yields a catalytic Au-(His)Chemical science · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dramatically higher rates for a variety of chemical reactions have been reported in microdroplets compared with those in the liquid bulk phase. However, the scale-up of microdroplet chemical synthesis has remained a major challenge to the practical application of microdroplet chemistry. Heated ultrasonic nebulization (HUN) was found as a new way for scaling up chemical synthesis in microdroplets. Four reactions were examined, a base-catalyzed Claisen-Schmidt condensation, an oximation reaction from a ketone, a two-phase oxidation reaction without the use of a phase-transfer-catalyst, and an Eschenmoser coupling reaction. These reactions show acceleration of one to three orders of magnitude (122, 23, 6536, and 62) in HUN microdroplets compared to the same reactions in bulk solution. Then, using the present method, the scale-up of the reactions was achieved at an isolated rate of 19 mg min
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.