ArticleChemical science2019
Supramolecular caging for cytosolic delivery of anionic probes.
Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Medical and Nonmedical Applications of Synthetic Transmembrane Anion Transporters.Chemical reviews · 2025Review
- Embracing Complexity: Peptides as Tunable Scaffolds in the Construction of Discrete Supramolecular Systems.Angewandte Chemie (International ed. in English) · 2025Review
- Aromatic Anion Carrier via Self-Assembly with Imidazolium-Fused Aromatic Amphiphiles.Precision chemistry · 2025Article
- Engineering a Surfactant Trap via Postassembly Modification of an Imine Cage.Chemistry of materials : a publication of the American Chemical Society · 2024Article
- Complexation Preferences of Dynamic Constitutional Frameworks as Adaptive Gene Vectors.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Dynamic Covalent Self-Assembly of Chloride- and Ion-Pair-Templated Cryptates.Angewandte Chemie (International ed. in English) · 2022Article
- Artificial transmembrane signal transduction mediated by dynamic covalent chemistry.Chemical science · 2021Article
- Late-stage functionalisation of alkyne-modified phospha-xanthene dyes: lysosomal imaging using an off-on-off type of pH probe.Chemical science · 2021Article
- Short oligoalanine helical peptides for supramolecular nanopore assembly and protein cytosolic delivery.RSC chemical biology · 2021Article
- Chimeric Drug Design with a Noncharged Carrier for Mitochondrial Delivery.Pharmaceutics · 2021Article
- Kinetics of Toehold-Mediated DNA Strand Displacement Depend on FeNano letters · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cytosolic delivery of hydrophilic, anionic molecular probes and therapeutics is a major challenge in chemical biology and medicine. Herein, we describe the design and synthesis of peptide-cage hybrids that allow an efficient supramolecular binding, cell membrane translocation and cytosolic delivery of a number of anionic dyes, including pyranine, carboxyfluorescein and several sulfonate-containing Alexa dyes. This supramolecular caging strategy is successful in different cell lines, and the dynamic carrier mechanism has been validated by U-tube experiments. The high efficiency of the reported approach allowed intracellular pH tracking by exploiting the ratiometric excitation of the pyranine fluorescent probe.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.