ArticleClinical interventions in aging2020
The Tilburg Frailty Indicator (TFI): New Evidence for Its Validity.
Article in Clinical interventions in aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06688591 (Effectiveness of an Evidence-based Multi-component Intervention Programme to Reduce Medication-related Problems Among Polymedicated Home-dwelling Older Adults), which is not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of an Evidence-based Multi-component Intervention Programme to Reduce Medication-related Problems Among Polymedicated Home-dwelling Older Adults: Protocol for a Multi-site Pilot Study of the OptiMed Clinical Trial
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Measures of Comorbidities and Frailty in Multiple Sclerosis-Systematic Review on Evidence and Applicability of Utilized Scoring Systems in Clinical Routine and Real-World Data.European journal of neurology · 2025Pooled it
- Effect of a protein intervention during resistance training with varying training intensities on muscle outcomes in frail community-dwelling older adults: a randomized controlled trial.The journal of nutrition, health & aging · 2026Trial
- Deepening the understanding of the structural validity of the Tilburg Frailty Indicator.Aging clinical and experimental research · 2023Trial
- Exploring Network Relationships Between Health Status and Frailty in COPD Patients with Multimorbidity: A Cross-Sectional Study.Journal of multidisciplinary healthcare · 2026Article
- Social Frailty in Older Adults: Proposal and Application of an Original Measurement Index.Annals of geriatric medicine and research · 2025Article
- Motor-cognitive interactions in older adults: reliability and comparison of Trail Walking and Stepping Trail Making Tests.European geriatric medicine · 2025Article
- Article
- Analysis of Frailty Indices Based on Sociodemographic and Clinical Determinants in Older Women.Healthcare (Basel, Switzerland) · 2025Article
- A biopsychosocial approach to improving multidimensional frailty status in community-dwelling older adults: a protocol for a cluster randomized controlled trial.BMC geriatrics · 2025Article
- Examining the severity of disability and vulnerability among older adults and its impact on elder abuse: a cross-sectional study.Scientific reports · 2025Article
- Factors associated with health-related quality of life among community-dwelling older adults: the APPCARE study.Scientific reports · 2024Article
- Correlates of frailty in older female cancer survivors.Journal of geriatric oncology · 2024Article
- Implementation of a value-based approach for older people who have suffered an acute myocardial infarction: study protocol.Frontiers in public health · 2024Article
- Internal consistency and construct validity of the Short Musculoskeletal Function Assessment (SMFA) in older adults.Annals of medicine · 2023Article
- Epigenetic and Metabolomic Biomarkers for Biological Age: A Comparative Analysis of Mortality and Frailty Risk.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Article
- Frailty in Kingdom of Saudi Arabia-Prevalence and Management, Where Are We?Healthcare (Basel, Switzerland) · 2023Article
- An Intervention Program to Reduce Medication-Related Problems Among Polymedicated Home-Dwelling Older Adults (OptiMed): Protocol for a Pre-Post, Multisite, Pilot, and Feasibility Study.JMIR research protocols · 2023Article
- Accelerated aging in people experiencing homelessness: A rapid review of frailty prevalence and determinants.Frontiers in public health · 2023Review
- Influencing factors of care dependence in patients with coronary heart disease after percutaneous coronary intervention-A cross-sectional study.Nursing open · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe Tilburg Frailty Indicator (TFI) is a self-report user-friendly questionnaire for assessing multidimensional frailty among community-dwelling older people. The main aim of this study is to re-evaluate the validity of the TFI, both cross-sectionally and longitudinally, focusing on the predictive value of the total TFI and its physical, psychological, and social domains for adverse outcomes disability, indicators of healthcare utilization, and falls.
methodsThe validity of the TFI was determined in a sample of 180 Dutch community-dwelling older people aged 70 years and older. The participants completed questionnaires including the TFI, the Groningen Activity Restriction Scale (GARS) for assessing disability, and questions with regard to health care utilization and falls in 2016 and again one year later.
resultsThe physical and psychological domains of the TFI were significantly correlated as expected with adverse outcomes disability, many indicators of healthcare utilization, and falls. Regression analyses showed that physical frailty was mostly responsible for the effect of frailty on the adverse outcomes. The cross-sectional and longitudinal predictive validity of total frailty with respect to disability and receiving personal care was excellent, evidenced by Areas Under the Curves (AUCs) >0.8. In most cases, using the cut-off point 5 for total frailty ensured the best values for sensitivity and specificity.
conclusionThe present study provided new, additional evidence for the validity of the TFI for assessing frailty in Dutch community-dwelling older people aiming to prevent or delay adverse outcomes, including disability.
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