ArticleClinical interventions in aging2020
Predicting the One-Year Prognosis and Mortality of Patients with Acute Ischemic Stroke Using Red Blood Cell Distribution Width Before Intravenous Thrombolysis.
Article in Clinical interventions in aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Red blood cell distribution width as a predictor of mortality and poor functional outcome after acute ischemic stroke: a meta-analysis and meta-regression.BMC neurology · 2024Pooled it
- Red blood cell distribution width-to-albumin ratio and in-hospital major adverse cardiovascular events in patients with acute myocardial infarction complicated by cardiogenic shock: a two-center retrospective cohort study.Frontiers in cardiovascular medicine · 2026Article
- Development and Validation of a Web-Based Machine Learning Model for Predicting Early Neurological Deterioration Following Stroke Thrombolysis: Multicenter Study.Journal of medical Internet research · 2025Article
- The link between red blood cell distribution width and 3-month prognosis in acute ischemic stroke patients: a secondary analysis of a cohort study.BMC neurology · 2025Article
- Association between red blood cell distribution width-to-albumin ratio and prognosis of patients with acute myocardial infarction.BMC cardiovascular disorders · 2023Article
- Hemoglobin to red cell distribution width ratio as a prognostic marker for ischemic stroke after mechanical thrombectomy.Frontiers in aging neuroscience · 2023Article
- Stroke and Emerging Blood Biomarkers: A Clinical Prospective.Neurology international · 2022Review
- Red cell distribution width is associated with stroke severity and unfavorable functional outcomes in ischemic stroke.Frontiers in neurology · 2022Article
- The difference in red blood cell distribution width from before to after thrombolysis as a prognostic factor in acute ischemic stroke patients: A 2-year follow-up.Frontiers in neurology · 2022Article
- RDW-to-ALB Ratio Is an Independent Predictor for 30-Day All-Cause Mortality in Patients with Acute Ischemic Stroke: A Retrospective Analysis from the MIMIC-IV Database.Behavioural neurology · 2022Article
- Association of Red Blood Cell Distribution Width with Stroke Prognosis Among Patients with Small Artery Occlusion: A Hospital-Based Prospective Follow-Up Study.International journal of general medicine · 2022Article
- Article
- Red cell index: A novel biomarker for 3-month mortality in acute ischemic stroke patients treated with intravenous thrombolysis.Brain and behavior · 2021Article
- Is Red Blood Cell Distribution Width Predictive of Fatigue After Acute Myocardial Infarction to Improve Nursing Care?Iranian journal of nursing and midwifery researchArticle
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeRed blood cell (RBC) distribution width (RDW) is known to reflect the heterogeneity of RBC volume, which may be associated with cardiovascular events or mortality after myocardial infarction. However, the association between RDW and stroke, especially regarding endpoints such as death, remains ambiguous. This study aimed to explore the prognostic value of RDW and its effect on mortality among patients with acute ischemic stroke (AIS) undergoing intravenous thrombolysis (IVT) after one year. PATIENTS AND
methodsWe retrospectively reviewed patients with AIS treated with IVT between January 2016 and March 2018. We grouped the patients according to modified ranking scale (MRS) scores as follows:0-2, favorable functional outcome group; and 3-6, unfavorable functional outcome. Predictors were determined using multivariate logistic regression (MVLR). The area under receiver-operating characteristic curve (AUC) was used to evaluate the predictive capability of variables. Furthermore, the Cox proportional hazard model was used to assess the contribution of risk factors to the outcome of death at one year later.
resultsMVLR analysis showed that RDW (odds ratio [OR], 1.179; 95% confidence interval [CI], 0.900-1.545; p = 0.232) was not an independent predictor of unfavorable functional outcome, but it (OR 1.371; 95% CI 1.109-1.696; p = 0.004) was an independent biomarker for all-cause mortality. The optimal RDW cut-off value to predict mortality was 14.65% (sensitivity: 42%, specificity: 88.3%, AUC: 0.649, p < 0.001). Furthermore, higher RDW (hazard ratio, 2.860; 95% CI, 1.724-4.745; p < 0.001) indicated a greater risk of death.
conclusionThe baseline RDW is a potential predictor of mortality in patients with AIS undergoing IVT, but RDW might not be associated with worse survival function among stroke survivors, which will help us to improve treatments and the management of patients with AIS.
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