ArticleiScience2020
Cell Membrane and Electron Transfer Engineering for Improved Synthesis of Menaquinone-7 in Bacillus subtilis.
Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Bibliometric Analysis of Probiotic Bacillus in Food Science: Evolution of Research Trends and Systematic Evaluation.Probiotics and antimicrobial proteins · 2025Pooled it
- Menaquinone biosynthesis inEngineering microbiology · 2026Review
- High-level production of vitamin K2 inSynthetic and systems biotechnology · 2026Article
- Engineering riboflavin-overproducingSynthetic and systems biotechnology · 2026Article
- Integrated Biofilm Modification and Transcriptional Analysis for Improving Fengycin Production in Bacillus amyloliquefaciens.Probiotics and antimicrobial proteins · 2025Article
- A Review of the Progress in the Microbial Biosynthesis of Prenylated Aromatic Compounds.Molecules (Basel, Switzerland) · 2025Review
- Enhancement of Menaquinone-7 production in Bacillus subtilis by optimizing the medium components through response surface methodology.Bioresources and bioprocessing · 2025Article
- Vitamin K (Menaquinone) from marine Kocuria sp. RAM1: optimization, characterization and potential in vitro biological activities.Microbial cell factories · 2025Article
- Production of menaquinone - 7 byJournal of food science and technology · 2025Article
- A High-Throughput Screening Strategy forMicroorganisms · 2025Article
- Natural pigments derived from plants and microorganisms: classification, biosynthesis, and applications.Plant biotechnology journal · 2025Review
- Combination of SPH and SP80 prolongs the lifespan ofFrontiers in microbiology · 2025Article
- Adaptive laboratory evolution for improved tolerance of vitamin K in Bacillus subtilis.Applied microbiology and biotechnology · 2024Article
- Increasing Vitamin KJournal of agricultural and food chemistry · 2024Article
- Advances in regulating vitamin KWorld journal of microbiology & biotechnology · 2023Review
- Brij-58 supplementation enhances menaquinone-7 biosynthesis and secretion in Bacillus natto.Applied microbiology and biotechnology · 2023Article
- Enhanced vitamin K2 production by engineered Bacillus subtilis during leakage fermentation.World journal of microbiology & biotechnology · 2023Article
- Characterization of a Riboflavin-Producing Mutant ofMicroorganisms · 2023Article
- Safety Evaluation ofMicroorganisms · 2022Article
- Enhancing menaquinone-7 biosynthesis by adaptive evolution of Bacillus natto through chemical modulator.Bioresources and bioprocessing · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The formation of biofilm facilitates the synthesis of valuable natural product menaquinone-7 (MK-7) in static culture of Bacillus subtilis, whereas the essential role and mechanism of biofilm in MK-7 synthesis have not been revealed. Herein, comparative transcriptomics show that the formation of biofilm affected MK-7 synthesis by changing the transcription levels of signal receptor (BSU02010), transmembrane transporter (BSU29340, BSU03070), and signal transduction (BSU02630). Moreover, we also found that oxalate decarboxylase OxdC has an important effect on electron generation and MK-7 synthesis, when the transcriptional level of NADH dehydrogenase decreases in static culture. Our results revealed that cell membrane and electron transfer are important factors in promoting MK-7 synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.