Evidence map›Paper›PMID 32109601›Full record

ArticleNeuroImage2020

Network segregation varies with neural distinctiveness in sensorimotor cortex.

Kaitlin Cassady, Holly Gagnon, Erin Freiburger, Poortata Lalwani, Molly Simmonite, Denise C Park, Scott J Peltier, Stephan F Taylor, Daniel H Weissman, Rachael D Seidler and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 53 citations in OpenAlex.

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  18. Dissociative Effects of Age on Neural Differentiation at the Category and Item Levels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  19. GABA levels decline with age: A longitudinal study.Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Kaitlin CassadyDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA. Electronic address: kcass@umich.edu.
Holly GagnonDepartment of Psychology, University of Utah, Salt Lake City, UT, USA.
Erin FreiburgerDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Poortata LalwaniDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Molly SimmoniteDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Denise C ParkResearch of the Center for Vital Longevity, University of Texas at Dallas, Dallas, TX, USA.
Scott J PeltierDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Stephan F TaylorDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Daniel H WeissmanDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Rachael D SeidlerDepartment of Applied Physiology & Kinesiology, University of Florida, Gainesville, FL, USA.
Thad A PolkDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · USMichigan Medicine · USThe University of Texas at Dallas · USUniversity of Florida · USUniversity of Utah · US

Funding

Investigating age-related neural dedifferentiation longitudinally and in Alzheimer’s pathologyR01AG050523 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI POLK, THAD A · 2016 to 2025
$5.7M
Somatosensory Dedifferentiation in the Aging BrainF31AG057205 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CASSADY, KAITLIN ELIZABETH · 2017 to 2018
$72k
NIA NIH HHS F31 AG057205NIA NIH HHS R01 AG050523
6 · The paper itself

Abstract

Normal aging is associated with declines in sensorimotor function. Previous studies have linked age-related behavioral declines to decreases in neural differentiation (i.e., dedifferentiation), including decreases in the distinctiveness of neural activation patterns and in the segregation of large-scale neural networks at rest. However, no studies to date have explored the relationship between these two neural measures and whether they explain the same aspects of behavior. To investigate these issues, we collected a battery of sensorimotor behavioral measures in older and younger adults and estimated (a) the distinctiveness of neural representations in sensorimotor cortex and (b) sensorimotor network segregation in the same participants. Consistent with prior findings, sensorimotor representations were less distinct and sensorimotor resting state networks were less segregated in older compared to younger adults. We also found that participants with the most distinct sensorimotor representations exhibited the most segregated sensorimotor networks. However, only sensorimotor network segregation was associated with individual differences in sensorimotor performance, particularly in older adults. These novel findings link network segregation to neural distinctiveness, but also suggest that network segregation may play a larger role in maintaining sensorimotor performance with age.

Indexed as

NeuronsAdultAgedAged, 80 and overAgingFemaleHand StrengthHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedMotor SkillsNerve NetReaction TimeSensorimotor CortexAgingDedifferentiationResting-stateSensorimotorTask activity

Identifiers

PMID32109601
PMCPMC7723993
OpenAlexW3008308061

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.