ArticleToxicology and applied pharmacology2020
Suppression of iron mobilization from lysosomes to mitochondria attenuates liver injury after acetaminophen overdose in vivo in mice: Protection by minocycline.
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Article in Toxicology and applied pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Ferroptosis in liver biology and diseases.Hepatology communications · 2026Review
- Hepatic STEAP4 promotes liver regeneration by regulating lysosomal iron homeostasis and membrane integrity in acetaminophen-induced liver injury.Hepatology (Baltimore, Md.) · 2026Article
- Mechanistic investigation of the crosstalk between hepatic ischemia-reperfusion injury and intestinal microbiota.Translational gastroenterology and hepatology · 2026Review
- Reactive oxygen species and peroxynitrite in acetaminophen-induced liver injury: Lipid peroxidation and ferroptosis-like cell death.Ferroptosis and oxidative stress · 2026Article
- Article
- The multiple mechanisms and modes of cell death after acetaminophen overdose.Exploration of digestive diseases · 2025Article
- Ferroptosis and Intrinsic Drug-induced Liver Injury by Acetaminophen and Other Drugs: A Critical Evaluation and Historical Perspective.Journal of clinical and translational hepatology · 2024Review
- Article
- Central Mechanisms of Acetaminophen Hepatotoxicity: Mitochondrial Dysfunction by Protein Adducts and Oxidant Stress.Drug metabolism and disposition: the biological fate of chemicals · 2024Review
- Acetaminophen Hepatotoxicity: Paradigm for Understanding Mechanisms of Drug-Induced Liver Injury.Annual review of pathology · 2024Review
- Mitochondrial P-JNK target, SAB (SH3BP5), in regulation of cell death.Frontiers in cell and developmental biology · 2024Review
- Functional foods and bioactive compounds: a comprehensive review on their role in mitigating drug-induced liver injury.Frontiers in nutrition · 2024Review
- The mitochondrial calcium uniporter mediates mitochondrial FeToxicology and applied pharmacology · 2023Article
- Article
- Review
- Mitochondrial Dysfunction and Chronic Liver Disease.Current issues in molecular biology · 2022Review
- The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice.Toxicology and applied pharmacology · 2022Article
- Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury.Cell biology and toxicology · 2022Article
- [Induction of peripheral blood mononuclear cells to hepatocyte-like cells and preliminary study of cell response to injury under the effect of acetaminophen].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022Article
- Oxidant Stress and Acetaminophen Hepatotoxicity: Mechanism-Based Drug Development.Antioxidants & redox signaling · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Jiangting HuCenter for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston, SC 29425, United States of America; Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, United States of America.
John J LemastersCenter for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston, SC 29425, United States of America; Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, United States of America; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, United States of America. Electronic address: JJLemasters@musc.edu.
Medical University of South Carolina · US
Funding
Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND N. DUBOIS · 2009 to 2026
$42.7MSOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALINGP20GM103542 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TEW, KENNETH D. · 2012 to 2020
$20.2MProteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DON C. ROCKEY · 2020 to 2026
$8.8MLIVER PRESERVATION FOR TRANSPLANTATIONR37DK037034 · NIDDK · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI LEMASTERS, JOHN J · 1998 to 2007
$4.0MMitochondrial depolarization, mitophagy, and mitochondrial DAMPs in ALDR01AA025379 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ZHI ZHONG · 2018 to 2026
$3.8MLIVER PRESERVATION FOR TRANSPLANTATIONR01DK037034 · NIDDK · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI LEMASTERS, JOHN J · 1986 to 2012
$3.1MAutophagy and Drug-Induced Liver InjuryR01DK102142 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI DING, WEN-XING, JAESCHKE, HARTMUT W. · 2014 to 2022
$2.7MMechanisms of I/R Injury to HepatocytesR01DK073336 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LEMASTERS, JOHN J · 2007 to 2017
$2.5MMUSC FACIL EXPANSION &RENOV: SLE C06RR015455 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CROUCH, ROSALIE K · 2002 to 2002
$2.0MVDAC in Ethanol and Aldehyde-Induced Mitochondrial DysfunctionR01AA021191 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LEMASTERS, JOHN J · 2014 to 2018
$1.7MTraining in Bioenergetics, Oxidative Stress and Metabolic SyndromeT32DK083262 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LEMASTERS, JOHN J · 2009 to 2018
$1.5MConfocal/Multiphoton Microscope UpgradeS10OD018113 · OD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LEMASTERS, JOHN J · 2015 to 2015
$570kNCI NIH HHS P30 CA138313NCRR NIH HHS C06 RR015455NIAAA NIH HHS R01 AA021191NIAAA NIH HHS R01 AA025379NIDDK NIH HHS P30 DK123704NIDDK NIH HHS R01 DK037034NIDDK NIH HHS R01 DK073336NIDDK NIH HHS R01 DK102142NIDDK NIH HHS R37 DK037034NIDDK NIH HHS R56 DK037034NIDDK NIH HHS T32 DK083262NIGMS NIH HHS P20 GM103542NIH HHS S10 OD018113
Abstract
Acetaminophen (APAP) overdose causes hepatotoxicity involving mitochondrial dysfunction. Previous studies showed that translocation of Fe
Indexed as
AcetaminophenAnalgesics, Non-NarcoticAnimalsAnti-Bacterial AgentsCells, CulturedCell SurvivalChemical and Drug Induced Liver InjuryDrug OverdoseHepatocytesHumansIronLysosomesMaleMiceMice, Inbred C57BLMinocyclineAcetaminophenAnalgesics, Non-NarcoticAnti-Bacterial AgentsIronMinocyclineAcetaminophenCalcium uniporterIronLiverMinocyclineMitochondria
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.