Evidence map›Paper›PMID 32109382›Full record

ArticleDevelopmental cell2020

Epithelial Migration and Non-adhesive Periderm Are Required for Digit Separation during Mammalian Development.

Ghaidaa Kashgari, Lina Meinecke, William Gordon, Bryan Ruiz, Jady Yang, Amy Lan Ma, Yilu Xie, Hsiang Ho, Maksim V Plikus, Qing Nie and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Developmental cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 30 citations in OpenAlex.

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  13. Dysregulation of Grainyhead-like 3 expression causes widespread developmental defects.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Ghaidaa KashgariDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Lina MeineckeDepartment of Mathematics, School of Physical Sciences, University of California, Irvine, Irvine, CA, USA; Department of Developmental & Cell Biology, School of the Biological Sciences, University of California, Irvine, Irvine, CA, USA.
William GordonDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Bryan RuizDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Jady YangDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Amy Lan MaDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Yilu XieThe Gavin Herbert Eye Institute, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Hsiang HoDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Maksim V PlikusDepartment of Developmental & Cell Biology, School of the Biological Sciences, University of California, Irvine, Irvine, CA, USA.
Qing NieDepartment of Mathematics, School of Physical Sciences, University of California, Irvine, Irvine, CA, USA; Department of Developmental & Cell Biology, School of the Biological Sciences, University of California, Irvine, Irvine, CA, USA.
James V JesterThe Gavin Herbert Eye Institute, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Bogi AndersenDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Medicine, School of Medicine, University of California, Irvine, Irvine, CA, USA. Electronic address: bogi@uci.edu.
University of California, Irvine · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Transcriptional Co-Regulators in EpidermisR01AR044882 · NIAMS · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI Bogi Andersen · 1998 to 2026
$9.0M
UCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSEN, BOGI, GANESAN, ANAND K · 2019 to 2025
$5.1M
Multiscale Models of Wound Cell Plasticity for RegenerationU01AR073159 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAI, XING, NIE, QING · 2018 to 2022
$3.5M
An epidermal mechanism for digit separationR21AR069962 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSEN, BOGI · 2017 to 2018
$374k
NCI NIH HHS P30 CA062203NIAMS NIH HHS P30 AR075047NIAMS NIH HHS R01 AR044882NIAMS NIH HHS R21 AR069962NIAMS NIH HHS U01 AR073159
6 · The paper itself

Abstract

The fusion of digits or toes, syndactyly, can be part of complex syndromes, including van der Woude syndrome. A subset of van der Woude cases is caused by dominant-negative mutations in the epithelial transcription factor Grainyhead like-3 (GRHL3), and Grhl3

Indexed as

Cell MovementAnimalsDNA-Binding ProteinsEpithelial CellsForelimbMiceMice, Inbred C57BLMorphogenesisSyndactylyToesTranscription FactorsDNA-Binding ProteinsGrhl3 protein, mouseTranscription Factorsdigit separationembryonic epidermisepithelial mechanismgrainyhead like-3interdigital cell deathlimb developmentperidermsyndactylyvan der Woude syndrome

Identifiers

PMID32109382
PMCPMC8237330
OpenAlexW3008794425

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.