Evidence map›Paper›PMID 32109373›Full record

ReviewTrends in immunology2020

The Fetal-Maternal Immune Interface in Uterus Transplantation.

Jasper Iske, Abdallah Elkhal, Stefan G Tullius

Abstract readReview
In one paragraph

Review in Trends in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Labor and Delivery Outcomes in Australian Mothers after Kidney Transplantation.Journal of the American Society of Nephrology : JASN · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Glymphatic System (En)during Inflammation.International journal of molecular sciences · 2021
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jasper IskeDivision of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Institute of Transplant Immunology, Integrated Research and Treatment Center Transplantation, Hannover Medical School, Hannover, Lower Saxony, Germany.
Abdallah ElkhalDivision of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Stefan G TulliusDivision of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: stullius@bwh.harvard.edu.

Funding

Senescent cells drive mt-DNA accumulation and inflamm-agingR01AG064165 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI TULLIUS, STEFAN GUNTHER · 2020 to 2024
$2.6M
The microbiota and allograft rejection: novel investigations into the consequences of obesityU01AI132898 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI ALEGRE, MARIA-LUISA, PERKINS, DAVID LINN · 2017 to 2021
$2.3M
Consequences of Aging on Immune Response and Transplant OutcomeR01AG039449 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI TULLIUS, STEFAN GUNTHER · 2012 to 2016
$1.6M
Consequences of Aging on Immune Response and Transplant OutcomeR56AG039449 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI TULLIUS, STEFAN GUNTHER · 2018 to 2018
$643k
NIAID NIH HHS U01 AI132898NIA NIH HHS R01 AG039449NIA NIH HHS R01 AG064165NIA NIH HHS R56 AG039449
6 · The paper itself

Abstract

Uterus transplants (UTxs) have been performed worldwide. Overall frequencies have been low, but globally initiated UTx programs are expected to increase clinical implementation. The uterus constitutes a unique immunological environment with specific features of tissue renewal and a receptive endometrium. Decidual immune cells facilitate embryo implantation and placenta development. Although UTx adds to the complexity of immunity during pregnancy and transplantation, the procedure provides a unique clinical and experimental model. We posit that understanding the distinct immunological properties at the interface of the transplanted uterus, the fetus and maternal circulation might provide valuable novel insights while improving outcomes for UTx. Here, we discuss immunological challenges and opportunities of UTx affecting mother, pregnancy and healthy livebirths.

Indexed as

FetusOrgan TransplantationUterusEmbryo ImplantationFemaleHumansPregnancy

Identifiers

PMID32109373
PMCPMC7879580

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.