ArticleNeuron2020
Activity-Dependent Plasticity of Axo-axonic Synapses at the Axon Initial Segment.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
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Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- Axo-axonic cells in neuropsychiatric disorders: a systematic review.Frontiers in cellular neuroscience · 2023Pooled it
- Cortical control of chandelier cells in neural codes.Frontiers in cellular neuroscience · 2022Pooled it
- Interneurons and network activity in the cerebral cortex: a developmental dialogue.Nature reviews. Neuroscience · 2026Review
- Astrocyte-mediated higher-order control of synaptic plasticity.Communications biology · 2026Article
- Chloride Homeostasis Failure in Human Disease: KCC2/NKCC1 Microdomain Dysfunction as a Driver of Cortical Network Collapse.International journal of molecular sciences · 2026Review
- Prefrontal chandelier cells encode stimulus salience to influence learning in male mice.Nature communications · 2026Article
- Developmental dysregulation of chandelier cell excitability in a mouse model of Dravet Syndrome.bioRxiv : the preprint server for biology · 2026Article
- Hippocampal Chandelier Cells Modulate Seizure Susceptibility and Severity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Transspinal temporal interference stimulation enhances neuroplasticity-associated responses and facilitates motor recovery after spinal cord injury in mice.Frontiers in neuroscience · 2026Article
- The First 30 Days Postnatal of the GABA Receptor: A Comprehensive Overview.Molecular neurobiology · 2025Review
- Interactions between homeostatic plasticity and statistical learning: A role for inhibition.Current opinion in neurobiology · 2025Review
- Theory of axo-axonic inhibition.PLoS computational biology · 2025Article
- Axon initial segment structure and function in health and disease.Physiological reviews · 2025Review
- Oligodendrocyte precursor cells facilitate neuronal lysosome release.Nature communications · 2025Article
- Specific and Plastic: Chandelier Cell-to-Axon Initial Segment Connections in Shaping Functional Cortical Network.Neuroscience bulletin · 2024Review
- Feedback inhibition by a descending GABAergic neuron regulates timing of escape behavior ineLife · 2024Article
- Axo-axonic synaptic input drives homeostatic plasticity by tuning the axon initial segment structurally and functionally.Science advances · 2024Article
- Dynamics of mature myelin.Nature neuroscience · 2024Review
- Article
- Reclusive chandeliers: Functional isolation of dentate axo-axonic cells after experimental status epilepticus.Progress in neurobiology · 2023Article
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5 authors at 2 institutions in 1 country.
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Abstract
The activity-dependent rules that govern the wiring of GABAergic interneurons are not well understood. Chandelier cells (ChCs) are a type of GABAergic interneuron that control pyramidal cell output through axo-axonic synapses that target the axon initial segment. In vivo imaging of ChCs during development uncovered a narrow window (P12-P18) over which axons arborized and formed connections. We found that increases in the activity of either pyramidal cells or individual ChCs during this temporal window result in a reversible decrease in axo-axonic connections. Voltage imaging of GABAergic transmission at the axon initial segment (AIS) showed that axo-axonic synapses were depolarizing during this period. Identical manipulations of network activity in older mice (P40-P46), when ChC synapses are inhibitory, resulted instead in an increase in axo-axonic synapses. We propose that the direction of ChC synaptic plasticity follows homeostatic rules that depend on the polarity of axo-axonic synapses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.