Evidence map›Paper›PMID 32109354›Full record

ArticleACS chemical biology2020

The Impact of Sustained Immunization Regimens on the Antibody Response to Oligomannose Glycans.

Dung N Nguyen, Richard L Redman, Satoru Horiya, Jennifer K Bailey, Bokai Xu, Robyn L Stanfield, J Sebastian Temme, Celia C LaBranche, Shiyu Wang, Avital A Rodal and 3 more

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Controlling timing and location in vaccines.Advanced drug delivery reviews · 2020
    Pooled it
  2. Article
  3. ACS central science · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Dung N NguyenDepartment of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, United States.
Richard L RedmanDepartment of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, United States.
Satoru HoriyaDepartment of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, United States.
Jennifer K BaileyDepartment of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, United States.
Bokai XuDepartment of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, United States.
Robyn L StanfieldDepartment of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, United States.
J Sebastian TemmeDepartment of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, United States.
Celia C LaBrancheDepartment of Surgery, Duke University Medical Center, Durham, North Carolina 27710, United States.
Shiyu WangDepartment of Biology, Brandeis University, Waltham, Massachusetts 02454-9110, United States.
Avital A RodalDepartment of Biology, Brandeis University, Waltham, Massachusetts 02454-9110, United States.
David C MontefioriDepartment of Surgery, Duke University Medical Center, Durham, North Carolina 27710, United States.
Ian A WilsonDepartment of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, United States.
Isaac J KraussDepartment of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, United States.ORCID 0000-0003-0984-4085
Brandeis University · USDuke Medical Center · USScripps Research Institute · US

Funding

Identification of neutralizing epitopes on SARS-CoV-2 spike for design of vaccines and small-molecule antiviralsUM1AI144462 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BURTON, DENNIS R. · 2019 to 2025
$201.6M
Structural studies of native-like SOSIP trimersP01AI110657 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI MOORE, JOHN P · 2015 to 2024
$35.4M
X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
Rational and Combinatorial Design of Immunogens to Elicit 2G12-like AntibodiesR01AI090745 · NIAID · BRANDEIS UNIVERSITY · PI KRAUSS, ISAAC JONATHAN · 2010 to 2022
$3.9M
Design of Immunogens to Elicit PGT122 like AntibodiesR01AI113737 · NIAID · BRANDEIS UNIVERSITY · PI KRAUSS, ISAAC JONATHAN · 2014 to 2018
$2.2M
The Effect of Extended Antigen Release on Carbohydrate Specificity of the Antibody ResponseR03AI136720 · NIAID · BRANDEIS UNIVERSITY · PI KRAUSS, ISAAC JONATHAN · 2018 to 2019
$163k
NIAID NIH HHS P01 AI110657NIAID NIH HHS R01 AI090745NIAID NIH HHS R01 AI113737NIAID NIH HHS R03 AI136720NIAID NIH HHS UM1 AI144462NIDA NIH HHS HHSN271201100016CNIGMS NIH HHS P41 GM103393
6 · The paper itself

Abstract

The high mannose patch (HMP) of the HIV envelope protein (Env) is the structure most frequently targeted by broadly neutralizing antibodies; therefore, many researchers have attempted to use mimics of this region as a vaccine immunogen. In our previous efforts, vaccinating rabbits with evolved HMP mimic glycopeptides containing Man

Indexed as

AIDS VaccinesAnimalsAntibodies, NeutralizingAntibody FormationBinding SitesGlycopeptidesGlycosylationHIV AntibodiesHIV Envelope Protein gp120HIV InfectionsHumansImmunizationMannosidasesOligosaccharidesProtein BindingProtein ConformationAIDS VaccinesAntibodies, NeutralizingGlycopeptidesHIV AntibodiesHIV Envelope Protein gp120MannosidasesoligomannosideOligosaccharidesSmall Molecule LibrariesVaccines, Conjugate

Identifiers

PMID32109354
PMCPMC7091532
OpenAlexW3008873145

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.