ArticlePhysiological reports2020
Radiation cystitis modeling: A comparative study of bladder fibrosis radio-sensitivity in C57BL/6, C3H, and BALB/c mice.
Article in Physiological reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 28 citations in OpenAlex.
- Bladder adaptive hydrogel scaffold with dual release, antimicrobial, immunomodulatory, and repair: DRIVER for urinary tract infections.Acta pharmaceutica Sinica. B · 2026Article
- Keratin 20 deficiency phenocopies human UAB and drives bladder fibrosis via a mechanotransduction-TGF-β axis.iScience · 2026Article
- Senescence-Driven Inflammation and Immune Dynamics in the Progression of Radiation Cystitis.Cells · 2026Article
- Androgen receptor signaling induces hemorrhage and angiogenesis in the irradiated bladder.Scientific reports · 2025Article
- Hyperbaric Oxygen Therapy for Patients With Viral or Radiation-Induced Hemorrhagic Cystitis.Cureus · 2025Article
- Advancements in Understanding and Managing Radiation Cystitis: A Comprehensive Review.Current urology reports · 2024Review
- Topographic modification of the extracellular matrix precedes the onset of bladder cancer.Matrix biology plus · 2024Article
- Mitochondria Energy Metabolism Depression as Novel Adjuvant to Sensitize Radiotherapy and Inhibit Radiation Induced-Pulmonary Fibrosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- KDM3B Single-Nucleotide Polymorphisms Impact Radiation Therapy Toxicity Through Circular RNA-Mediated KDM3B Expression and Inflammatory Responses.International journal of radiation oncology, biology, physics · 2024Article
- Identification of Molecular Mechanisms in Radiation Cystitis: Insights from RNA Sequencing.International journal of molecular sciences · 2024Article
- Progressive alteration of murine bladder elasticity in actinic cystitis detected by Brillouin microscopy.Scientific reports · 2024Article
- Article
- Bladder malignancy as a cause of spontaneous bladder rupture: A systematic review.BJUI compass · 2024Review
- Defining the molecular fingerprint of bladder and kidney fibroblasts.American journal of physiology. Renal physiology · 2023Review
- Micro-mechanical fingerprints of the rat bladder change in actinic cystitis and tumor presence.Communications biology · 2023Article
- Mesenchymal stem cells limit vascular and epithelial damage and restore the impermeability of the urothelium in chronic radiation cystitis.Stem cell research & therapy · 2023Article
- Studies of ultrastructure, gene expression, and marker analysis reveal that mouse bladder PDGFRAAmerican journal of physiology. Renal physiology · 2022Article
- Molecular Mechanisms and Key Processes in Interstitial, Hemorrhagic and Radiation Cystitis.Biology · 2022Review
- Increased extracellular matrix stiffness accompanies compromised bladder function in a murine model of radiation cystitis.Acta biomaterialia · 2022Article
- Understanding Molecular Mechanisms and Identifying Key Processes in Chronic Radiation Cystitis.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
A subset of patients receiving radiation therapy for pelvic cancer develop radiation cystitis, a complication characterized by mucosal cell death, inflammation, hematuria, and bladder fibrosis. Radiation cystitis can reduce bladder capacity, cause incontinence, and impair voiding function so severely that patients require surgical intervention. Factors influencing onset and severity of radiation cystitis are not fully known. We tested the hypothesis that genetic background is a contributing factor. We irradiated bladders of female C57BL/6, C3H, and BALB/c mice and evaluated urinary voiding function, bladder shape, histology, collagen composition, and distribution of collagen-producing cells. We found that the genetic background profoundly affects the severity of radiation-induced bladder fibrosis and urinary voiding dysfunction. C57BL/6 mice are most susceptible and C3H mice are most resistant. Irradiated C57BL/6 mouse bladders are misshapen and express more abundant collagen I and III proteins than irradiated C3H and BALB/c bladders. We localized Col1a1 and Col3a1 mRNAs to FSP1-negative stromal cells in the bladder lamina propria and detrusor. The number of collagen I and collagen III-producing cells can predict the average voided volume of a mouse. Collectively, we show that genetic factors confer sensitivity to radiation cystitis, establish C57BL/6 mice as a sensitive preclinical model, and identify a potential role for FSP1-negative stromal cells in radiation-induced bladder fibrosis.
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