Evidence map›Paper›PMID 32109293›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020

Frequency and Predictors of Tenofovir-diphosphate Detection Among Young Kenyan Women in a Real-world Pre-exposure Prophylaxis Implementation Program.

Jillian Pintye, John Kinuthia, Felix Abuna, Kenneth Mugwanya, Harison Lagat, Julia C Dettinger, Daniel Odinga, Joseph Sila, Peter L Anderson, Grace John-Stewart and 1 more

Open access · greenAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  7. Frontiers in pediatrics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Jillian PintyeDepartment of Global Health, University of Washington, Seattle, Washington, USA.
John KinuthiaDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Felix AbunaDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Kenneth MugwanyaDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Harison LagatDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Julia C DettingerDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Daniel OdingaDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Joseph SilaDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Peter L AndersonDepartment of Pharmaceutical Sciences, University of Colorado, Aurora, Colorado, USA.
Grace John-StewartDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Jared M BaetenDepartment of Global Health, University of Washington, Seattle, Washington, USA.
University of Washington · USKenyatta National Hospital · KEUniversity of Colorado Anschutz Medical Campus · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Evaluating Infant PrEP Exposure During Pregnancy and BreastfeedingR01HD100201 · NICHD · UNIVERSITY OF WASHINGTON · PI PINTYE, JILLIAN · 2019 to 2023
$3.4M
PrEP optimized for mothers (PrOM): efficient PrEP integration in MCH clinicsR01HD094630 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C., KOHLER, PAMELA · 2017 to 2021
$3.3M
A differentiated care model to improve the efficiency of PrEP delivery in KenyaR00MH118134 · NIMH · UNIVERSITY OF WASHINGTON · PI MUGWANYA, KENNETH KIGGUNDU · 2019 to 2021
$743k
Assessing Mother and Infant Antiretroviral Exposure Using Hair MeasuresR21AI138618 · NIAID · UNIVERSITY OF WASHINGTON · PI GANDHI, MONICA, PINTYE, JILLIAN · 2018 to 2019
$459k
A differentiated care model to improve the efficiency of PrEP delivery in KenyaK99MH118134 · NIMH · UNIVERSITY OF WASHINGTON · PI MUGWANYA, KENNETH KIGGUNDU · 2018 to 2018
$123k
NIAID NIH HHS P30 AI027757NIAID NIH HHS R21 AI138618NICHD NIH HHS R01 HD094630NICHD NIH HHS R01 HD100201NIMH NIH HHS K99 MH118134NIMH NIH HHS R00 MH118134
6 · The paper itself

Abstract

In a pre-exposure prophylaxis program for Kenyan women, we detected tenofovir-diphosphate in 61% (125/201) of randomly selected dried blood spots collected at the first follow-up visit. Tenofovir-diphosphate was detected more frequently among women who had partners living with human immunodeficiency virus, who were not pregnant, and who were ≥24 years.

Indexed as

Anti-HIV AgentsHIV InfectionsPre-Exposure ProphylaxisDiphosphatesEmtricitabineFemaleHumansKenyaMedication AdherencePregnancyTenofovirAnti-HIV AgentsDiphosphatesEmtricitabineTenofoviradherenceHIV/AIDSpre-exposure prophylaxiswomen

Identifiers

PMID32109293
PMCPMC7713682
OpenAlexW3007356996

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.