Evidence map›Paper›PMID 32109061›Full record

ArticleJournal of the American Chemical Society2020

Selective Enrichment of A-to-I Edited Transcripts from Cellular RNA Using Endonuclease V.

Steve D Knutson, Robert A Arthur, H Richard Johnston, Jennifer M Heemstra

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Epitranscriptomic Analysis of A-to-I RNA Editing and mInternational journal of molecular sciences · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. ncRNA Editing: Functional Characterization and Computational Resources.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Regulation and functions of non-mNature reviews. Molecular cell biology · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. Absolute quantification of single-base mNature biotechnology · 2023
    Article
  17. Article
  18. Article
  19. Detection technologies for RNA modifications.Experimental & molecular medicine · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Steve D KnutsonDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.ORCID 0000-0001-6822-464X
Robert A ArthurEmory Integrated Computational Core, Emory Integrated Core Facilities, Emory University, Atlanta, Georgia 30322, United States.
H Richard JohnstonDepartment of Human Genetics, Emory University, Atlanta, Georgia 30322, United States.
Jennifer M HeemstraDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.ORCID 0000-0002-7691-8526
Emory University · US

Funding

Fluorescent mRNA Labeling Using Self-Alkylating RibozymesR01GM116991 · NIGMS · UNIVERSITY OF UTAH · PI HEEMSTRA, JENNIFER MARGARET · 2016 to 2020
$1.5M
NIGMS NIH HHS R01 GM116991
6 · The paper itself

Abstract

Creating accurate maps of A-to-I RNA editing activity is vital to improving our understanding of the biological role of this process and harnessing it as a signal for disease diagnosis. Current RNA sequencing techniques are susceptible to random sampling limitations due to the complexity of the transcriptome and require large amounts of RNA material, specialized instrumentation, and high read counts to accurately interrogate A-to-I editing sites. To address these challenges, we show that

Indexed as

RNA EditingCalciumDeoxyribonuclease (Pyrimidine Dimer)Escherichia coliHigh-Throughput Nucleotide SequencingHumansInosineRNA, MessengerSequence Analysis, RNACalciumDeoxyribonuclease (Pyrimidine Dimer)InosineRNA, Messenger

Identifiers

PMID32109061
PMCPMC7286354
OpenAlexW3008002335

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.