Evidence map›Paper›PMID 32109009›Full record

ArticleBrain and behavior2020

Global DNA methylation and cognitive and behavioral outcomes at 4 years of age: A cross-sectional study.

Rachael M Taylor, Roger Smith, Clare E Collins, David Mossman, Michelle W Wong-Brown, Eng-Cheng Chan, Tiffany-Jane Evans, John R Attia, Nick Buckley, Karen Drysdale and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rachael M TaylorPriority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.ORCID 0000-0002-1895-4123
Roger SmithPriority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.
Clare E CollinsFaculty of Health and Medicine, School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.
David MossmanHunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Michelle W Wong-BrownHunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Eng-Cheng ChanPriority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.
Tiffany-Jane EvansHunter Medical Research Institute, New Lambton Heights, NSW, Australia.
John R AttiaFaculty of Health and Medicine, School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.
Nick BuckleySchool of Psychology and Exercise Science, Murdoch University, Murdoch, WA, Australia.
Karen DrysdaleFaculty of Science, School Psychology, University of Newcastle, Callaghan, NSW, Australia.
Tenele SmithPriority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.
Trent ButlerPriority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.
Alexis J HureFaculty of Health and Medicine, School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.

Funding

John Hunter Charitable Trust G1700379
6 · The paper itself

Abstract

backgroundAccumulating evidence suggests that breastfeeding exclusivity and duration are positively associated with child cognition. This study investigated whether DNA methylation, an epigenetic mechanism modified by nutrient intake, may contribute to the link between breastfeeding and child cognition. The aim was to quantify the relationship between global DNA methylation and cognition and behavior at 4 years of age.

methodsChild behavior and cognition were measured at age 4 years using the Wechsler Preschool and Primary Scale of Intelligence, third version (WPPSI-III), and Child Behavior Checklist (CBC). Global DNA methylation (%5-methylcytosines (%5mC)) was measured in buccal cells at age 4 years, using an enzyme-linked immunosorbent assay (ELISA) commercial kit. Linear regression models were used to quantify the statistical relationships.

resultsData were collected from 73 children recruited from the Women and Their Children's Health (WATCH) study. No statistically significant associations were found between global DNA methylation levels and child cognition or behavior (p > .05), though the estimates of effect were consistently negative. Global DNA methylation levels in males were significantly higher than in females (median %5mC: 1.82 vs. 1.03, males and females, respectively, (p < .05)).

conclusionNo association was found between global DNA methylation and child cognition and behavior; however given the small sample, this study should be pooled with other cohorts in future meta-analyses.

Indexed as

DNA MethylationChild BehaviorChild, PreschoolCognitionCross-Sectional StudiesFemaleHumansMalebehaviorcognitionglobal DNA methylationnutritionone-carbon metabolismpostnatal

Identifiers

PMID32109009
PMCPMC7177573

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.