Evidence map›Paper›PMID 32109007›Full record

ReviewAdvanced healthcare materials2020

From Silk Spinning to 3D Printing: Polymer Manufacturing using Directed Hierarchical Molecular Assembly.

Xuan Mu, Vincent Fitzpatrick, David L Kaplan

Open access · greenAbstract readReview
In one paragraph

Review in Advanced healthcare materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 95 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. New Frontiers in 3D Printing Using Biocompatible Polymers.International journal of molecular sciences · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Silk fibroin-based inks forBioactive materials · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Engineering Three-Dimensional Vascularized Cardiac Tissues.Tissue engineering. Part B, Reviews · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Xuan MuDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Vincent FitzpatrickDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
David L KaplanDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.ORCID 0000-0002-9245-7774
Tufts University · US

Funding

Translational Bioreactors - Engineering Complex TissuesP41EB002520 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2004 to 2018
$16.7M
Tissue Engineering Resource Center: TTDP41EB027062 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gordana Vunjak-Novakovic · 2019 to 2026
$12.6M
Models to Predict Protein Biomaterial PerformanceU01EB014976 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI BUEHLER, MARKUS J., KAPLAN, DAVID L. · 2012 to 2020
$5.2M
Functional three dimensional brain-like tissues to study mechanisms of traumatic brain injuryR01NS092847 · NINDS · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2015 to 2019
$1.8M
Injectable Gels for Tissue AugmentationR01EB021264 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI HOUSE, MICHAEL DOUGLAS, KAPLAN, DAVID L. · 2016 to 2019
$1.4M
NIBIB NIH HHS P41 EB002520NIBIB NIH HHS P41 EB027062NIBIB NIH HHS R01 EB021264NIBIB NIH HHS U01 EB014976NINDS NIH HHS R01 NS092847
6 · The paper itself

Abstract

Silk spinning offers an evolution-based manufacturing strategy for industrial polymer manufacturing, yet remains largely inaccessible as the manufacturing mechanisms in biological and synthetic systems, especially at the molecular level, are fundamentally different. The appealing characteristics of silk spinning include the sustainable sourcing of the protein material, the all-aqueous processing into fibers, and the unique material properties of silks in various formats. Substantial progress has been made to mimic silk spinning in artificial manufacturing processes, despite the gap between natural and artificial systems. This report emphasizes the universal spinning conditions utilized by both spiders and silkworms to generate silk fibers in nature, as a scientific and technical framework for directing molecular assembly into high-performance structures. The preparation of regenerated silk feedstocks and mimicking native spinning conditions in artificial manufacturing are discussed, as is progress and challenges in fiber spinning and 3D printing of silk-composites. Silk spinning is a biomimetic model for advanced and sustainable artificial polymer manufacturing, offering benefits in biomedical applications for tissue scaffolds and implantable devices.

Indexed as

BombyxSpidersAnimalsPolymersPrinting, Three-DimensionalSilkPolymersSilkbiomimeticsliquid crystalsself-assemblysilkspinningsustainability

Identifiers

PMID32109007
PMCPMC7415583
OpenAlexW3008523568

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.