Evidence map›Paper›PMID 32108365›Full record

ReviewMuscle & nerve2020

Conference report on contractures in musculoskeletal and neurological conditions.

Glen H Nuckolls, Kathi Kinnett, Sudarshan Dayanidhi, Andrea A Domenighetti, Tina Duong, Yetrib Hathout, Michael W Lawlor, Sabrina S M Lee, S Peter Magnusson, Craig M McDonald and 13 more

Open access · greenAbstract readReview
In one paragraph

Review in Muscle & nerve, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 17 institutions in 2 countries.

Glen H NuckollsDivision of Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.ORCID 0000-0002-7466-6433
Kathi KinnettParent Project Muscular Dystrophy, Hackensack, New Jersey.
Sudarshan DayanidhiThe Shirley Ryan AbilityLab, Chicago, Illinois.
Andrea A DomenighettiThe Shirley Ryan AbilityLab, Chicago, Illinois.
Tina DuongDepartment of Neurology, Stanford University, Palo Alto, California.
Yetrib HathoutSchool of Pharmacy and Pharmaceutical Sciences, Binghamton University, Johnson City, New York.
Michael W LawlorDepartment of Pathology and Laboratory Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Sabrina S M LeePhysical Therapy and Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
S Peter MagnussonDepartment of Physical and Occupational Therapy, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Craig M McDonaldDepartment of Physical Medicine & Rehabilitation, University of California Davis School of Medicine, Sacramento, California.
Elizabeth M McNallyCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Natalie F MillerCenter for Gene Therapy, Nationwide Children's Hospital, Columbus, Ohio.
Bradley B OlwinDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Colorado.
Preeti RaghavanRusk Rehabilitation, New York University School of Medicine, New York, New York.
Thomas J RobertsEcology and Evolutionary Biology, Brown University, Providence, Rhode Island.
Seward B RutkoveDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.ORCID 0000-0002-6375-3312
John F SarwarkDepartment of Orthopaedic Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Claudia R SenesacPhysical Therapy Department, College of Public Health and Health Professions, University of Florida, Gainesville, Florida.
Leslie F VogelDepartment of Rehabilitation, Seattle Children's Hospital, Seattle, Washington.ORCID 0000-0002-0414-1228
Glenn A WalterDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, Florida.
Rebecca J WillcocksPhysical Therapy Department, College of Public Health and Health Professions, University of Florida, Gainesville, Florida.
William Z RymerThe Shirley Ryan AbilityLab, Chicago, Illinois.
Richard L LieberThe Shirley Ryan AbilityLab, Chicago, Illinois.ORCID 0000-0002-7203-4520
Shirley Ryan AbilityLab · USNorthwestern University · USUniversity of Florida Health · USBeth Israel Deaconess Medical Center · USBinghamton University · USBrown University · USFrederiksberg Hospital · DKMedical College of Wisconsin · USNational Institute of Neurological Disorders and Stroke · USNationwide Children's Hospital · USPalo Alto University · USParent Project Muscular Dystrophy · USRusk Rehabilitation · USSeattle Children's Hospital · USUniversity of California, Davis · USUniversity of Colorado Boulder · USUniversity of Florida · US

Funding

SARCOGLYCAN IN MYOPATHY AND MUSCLE MEMBRANE STABILITYR01HL061322 · NHLBI · UNIVERSITY OF CHICAGO · PI MCNALLY, ELIZABETH M · 1999 to 2022
$7.5M
The Role of Syndecans in Satellite Cell FunctionR01AR049446 · NIAMS · UNIVERSITY OF COLORADO AT BOULDER · PI Bradley B Olwin · 2005 to 2026
$7.2M
Replicative Potential of Muscle Stem CellsR01AR070360 · NIAMS · UNIVERSITY OF COLORADO · PI Bradley B Olwin · 2017 to 2026
$4.2M
Regulating fibrosis and growth through latent TGFbeta binding proteinsR01HL140938 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MCNALLY, ELIZABETH M · 2018 to 2021
$1.6M
Intramural NIH HHS Z99 NS999999NHLBI NIH HHS R01 HL061322NHLBI NIH HHS R01 HL140938NIAMS NIH HHS R01 AR049446NIAMS NIH HHS R01 AR070360
6 · The paper itself

Abstract

Limb contractures are debilitating complications associated with various muscle and nervous system disorders. This report summarizes presentations at a conference at the Shirley Ryan AbilityLab in Chicago, Illinois, on April 19-20, 2018, involving researchers and physicians from diverse disciplines who convened to discuss current clinical and preclinical understanding of contractures in Duchenne muscular dystrophy, stroke, cerebral palsy, and other conditions. Presenters described changes in muscle architecture, activation, extracellular matrix, satellite cells, and muscle fiber sarcomeric structure that accompany or predispose muscles to contracture. Participants identified ongoing and future research directions that may lead to understanding of the intersecting factors that trigger contractures. These include additional studies of changes in muscle, tendon, joint, and neuronal tissues during contracture development with imaging, molecular, and physiologic approaches. Participants identified the requirement for improved biomarkers and outcome measures to identify patients likely to develop contractures and to accurately measure efficacy of treatments currently available and under development.

Indexed as

Cerebral PalsyChicagoContractureEducationHumansMuscular Dystrophy, DuchenneMusculoskeletal DiseasesNervous System DiseasesResearch Reportcerebral palsycontractureDuchenne muscular dystrophymusclestroke

Identifiers

PMID32108365
PMCPMC7229996
OpenAlexW3007389686

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.