Evidence map›Paper›PMID 32108351›Full record

SynthesisJournal of medical virology2020

Clinical characteristics of hospitalized patients with SARS-CoV-2 infection: A single arm meta-analysis.

Pengfei Sun, Shuyan Qie, Zongjian Liu, Jizhen Ren, Kun Li, Jianing Xi

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of medical virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 270 papers, 24 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
270citing papers in PubMed, 24 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

270 citing papers in PubMed, 24 syntheses or guidelines pooled it.

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  4. Clinical and laboratory findings of COVID-19: A systematic review and meta-analysis.Journal of the Formosan Medical Association = Taiwan yi zhi · 2021
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  8. COVID-19 and healthcare workers: A systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
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210 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Pengfei SunDepartment of Plastic Surgery, Zibo Central Hospital, Zibo, China.
Shuyan QieDepartment of Rehabilitation, Beijing Rehabilitation Hospital of Capital Medical University, Beijing, China.
Zongjian LiuDepartment of Rehabilitation, Beijing Rehabilitation Hospital of Capital Medical University, Beijing, China.
Jizhen RenDepartment of Plastic Surgery, Affiliated Hospital of Qingdao University, Qingdao, China.
Kun LiDepartment of Plastic Surgery, Qingdao Eighth People's Hospital, Qingdao, China.
Jianing XiDepartment of Respiratory Rehabilitation, Beijing Rehabilitation Hospital of Capital Medical University, Beijing, China.ORCID 0000-0002-8405-2355

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe aim to summarize reliable evidence of evidence-based medicine for the treatment and prevention of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by analyzing all the published studies on the clinical characteristics of patients with SARS-CoV-2.

methodsPubMed, Cochrane Library, Embase, and other databases were searched. Several studies on the clinical characteristics of SARS-CoV-2 infection were collected for meta-analysis.

resultsTen studies were included in Meta-analysis, including a total number of 50466 patients with SARS-CoV-2 infection. Meta-analysis shows that, among these patients, the incidence of fever was 0.891 (95% CI: 0.818, 0.945), the incidence of cough was 0.722 (95% CI: 0.657, 0.782), and the incidence of muscle soreness or fatigue was 0.425 (95% CI: 0.213, 0.652). The incidence of acute respiratory distress syndrome (ARDS) was 0.148 (95% CI: 0.046, 0.296), the incidence of abnormal chest computer tomography (CT) was 0.966 (95% CI: 0.921, 0.993), the percentage of severe cases in all infected cases was 0.181 (95% CI: 0.127, 0.243), and the case fatality rate of patients with SARS-CoV-2 infection was 0.043 (95% CI: 0.027, 0.061).

conclusionFever and cough are the most common symptoms in patients with SARS-CoV-2 infection, and most of these patients have abnormal chest CT examination. Several people have muscle soreness or fatigue as well as ARDS. Diarrhea, hemoptysis, headache, sore throat, shock, and other symptoms are rare. The case fatality rate of patients with SARS-CoV-2 infection is lower than that of Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). This meta-analysis also has limitations, so the conclusions of this Meta-analysis still need to be verified by more relevant studies with more careful design, more rigorous execution, and larger sample size.

Indexed as

PandemicsBetacoronavirusChinaCoronavirus InfectionsCoughCOVID-19FatigueFeverHumansPneumonia, ViralRespiratory InsufficiencyRetrospective StudiesSARS-CoV-2Survival AnalysisTomography, X-Ray Computed2019-nCoVclinical symptomscoronavirusmeta-analysisSARS-CoV-2

Identifiers

PMID32108351
PMCPMC7228255

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.