Evidence map›Paper›PMID 32108172›Full record

ArticleScientific reports2020

Comparison of experimental peri-implantitis models after application of ex vivo BMP2 gene therapy using periodontal ligament stem cells.

Shin-Young Park, Kyoung-Hwa Kim, Sungtae Kim, Sang-Hoon Rhee, In-Sung Yeo, Seong-Joo Heo, Yong-Moo Lee, Yang-Jo Seol

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Harnessing biomolecules for bioinspired dental biomaterials.Journal of materials chemistry. B · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Shin-Young ParkDepartment of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, 03080, Korea.
Kyoung-Hwa KimDepartment of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, 03080, Korea.
Sungtae KimDepartment of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, 03080, Korea.
Sang-Hoon RheeDepartment of Dental Biomaterials Science, School of Dentistry, Seoul National University, Seoul, 03080, Korea.
In-Sung YeoDepartment of Prosthodontics and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, 03080, Korea.ORCID http://orcid.org/0000-0002-6780-2601
Seong-Joo HeoDepartment of Prosthodontics and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, 03080, Korea.
Yong-Moo LeeDepartment of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, 03080, Korea.
Yang-Jo SeolDepartment of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, 03080, Korea. yjseol@snu.ac.kr.
Seoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peri-implantitis is an inflammatory disease that results in bone destruction around dental implants. A preclinical study using beagle models is frequently performed prior to clinical application in dentistry. Previously, we proposed an immediate peri-implantitis experimental model with a shorter experimental duration and less expense than the conventional experimental model. However, the differences in the regenerative outcomes between the immediate and conventional models were not fully revealed. In this study, we aimed to compare the regenerative outcomes between both models when ex vivo BMP2 gene therapy using autologous periodontal ligament stem cells (B2/PDLSCs) was applied to peri-implantitis defects. The results showed that the defect depths were significantly different between both models. New bone formation occurred in both models, but there were significant differences between the models. More than 70% of the defects were filled with newly formed bone in the conventional model, whereas 30-40% of the defects were filled in the immediate model. However, after adjustment for the differences in the defect depths between the models, the statistically significant differences in the regenerative outcomes between the models were lost. In conclusion, the inferior regenerative outcome of an immediate peri-implantitis model at B2/PDLSCs transplantation resulted from the defect depths, not the model itself.

Indexed as

AnimalsBone Morphogenetic Protein 2Dental ImplantsDogsGenetic TherapyGuided Tissue Regeneration, PeriodontalHumansModels, AnimalPeri-ImplantitisPeriodontal LigamentStem CellsStem Cell TransplantationBMP2 protein, humanBone Morphogenetic Protein 2Dental Implants

Identifiers

PMID32108172
PMCPMC7046768
OpenAlexW3009039933

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.