ArticleScientific reports2020
Brainstem volume mediates seasonal variation in depressive symptoms: A cross sectional study in the UK Biobank cohort.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Genome-wide gene-environment interaction study uncovers 162 vitamin D status variants using a precise ambient UVB measure.Nature communications · 2025Article
- Temporal analysis of posts on a Japanese online message board for suicide risk monitoring.BMC psychiatry · 2025Article
- Observational
- Circadian Rhythms Tied to Changes in Brain Morphology in a Densely Sampled Male.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Circadian rhythms tied to changes in brain morphology in a densely-sampled male.bioRxiv : the preprint server for biology · 2024Article
- A brain circuit and neuronal mechanism for decoding and adapting to change in daylength.bioRxiv : the preprint server for biology · 2023Article
- Seasonality of brain function: role in psychiatric disorders.Translational psychiatry · 2023Review
- Amygdala and subregion volumes are associated with photoperiod and seasonal depressive symptoms: A cross-sectional study in the UK Biobank cohort.The European journal of neuroscience · 2022Article
- Predictability of Seasonal Mood Fluctuations Based on Self-Report Questionnaires and EEG Biomarkers in a Non-clinical Sample.Frontiers in psychiatry · 2022Article
- Circadian Rhythms of the Hypothalamus: From Function to Physiology.Clocks & sleep · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Seasonal differences in mood and depressive symptoms affect a large percentage of the general population, with seasonal affective disorder (SAD) representing the most common presentation. SAD affects up to 3% of the world's population, and it tends to be more predominant in females than males. The brainstem has been shown to be affected by photoperiodic changes, and that longer photoperiods are associated with higher neuronal density and decreased depressive-like behaviours. We predict that longer photoperiod days are associated with larger brainstem volumes and lower depressive scores, and that brainstem volume mediates the seasonality of depressive symptoms. Participants (N = 9289, 51.8% females and 48.1% males) ranging in age from 44 to 79 years were scanned by MRI at a single location. Photoperiod was found to be negatively correlated with low mood and anhedonia in females while photoperiod was found to be positively correlated with brainstem volumes. In females, whole brainstem, pons and medulla volumes individually mediated the relationship between photoperiod and both anhedonia and low mood, while midbrain volume mediated the relationship between photoperiod and anhedonia. No mediation effects were seen in males. Our study extends the understanding of the neurobiological factors that contribute to the pathophysiology of seasonal mood variations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.