Evidence map›Paper›PMID 32108041›Full record

ArticleCancer genomics & proteomics

Tumor Mutational Patterns and Infiltrating Lymphocyte Density in Young and Elderly Patients With Breast Cancer.

Adamantia Nikolaidi, Vassiliki Kotoula, Georgia-Angeliki Koliou, Eleni Giannoulatou, Kyriaki Papadopoulou, Flora Zagouri, George Pentheroudakis, Helen Gogas, Mattheos Bobos, Kyriakos Chatzopoulos and 10 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 14 institutions in 3 countries.

Adamantia NikolaidiOncology Department Mitera Hospital, Athens, Greece mantonikolaidi@gmail.com hecogoff@otenet.gr.
Vassiliki KotoulaDepartment of Pathology, School of Health Sciences, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Georgia-Angeliki KoliouSection of Biostatistics, Hellenic Cooperative Oncology Group, Data Office, Athens, Greece.
Eleni GiannoulatouBioinformatics and Systems Medicine Laboratory, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.
Kyriaki PapadopoulouLaboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.
Flora ZagouriDepartment of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece.
George PentheroudakisDepartment of Medical Oncology, Medical School, University of Ioannina, Ioannina, Greece.
Helen GogasFirst Department of Medicine, Laiko General Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece.
Mattheos BobosLaboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.
Kyriakos ChatzopoulosLaboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.
Georgios OikonomopoulosSecond Department of Medical Oncology, Metropolitan Hospital, Piraeus, Greece.
Dimitrios PectasidesOncology Section, Second Department of Internal Medicine, Hippokration Hospital, Athens, Greece.
Emmanouil SaloustrosDepartment of Oncology, University Hospital of Larissa, Larissa, Greece.
Niki ArnogiannakiDepartment of Surgical Pathology, Saint Savvas Anticancer Hospital, Athens, Greece.
Irene NicolaouDepartment of Histopathology, Agii Anagriri Hospital, Athens, Greece.
Pavlos PapakostasOncology Unit, Hippokration Hospital, Athens, Greece.
Iliada BompolakiOncology Department, General Hospital of Chania, Chania, Greece.
Gerasimos AravantinosSecond Department of Medical Oncology, Agii Anargiri Cancer Hospital, Athens, Greece.
Ilias AthanasiadisOncology Department Mitera Hospital, Athens, Greece.
George FountzilasLaboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.
Aristotle University of Thessaloniki · GRHippocration General Hospital · GRHospital Agioi Anargyroi · GRMitera Hospital · GRAlexandra Hospital · GRChania General Hospital ”St. George” · GRHellenic Cooperative Oncology Group · GRLaiko General Hospital of Athens · GRLimassol General Hospital · CYMetropolitan Hospital · GRSt Savas Hospital · GRUniversity Hospital of Larissa · GRUniversity of Ioannina · GRVictor Chang Cardiac Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimAge may pertain to different tumor genotype characteristics which may interfere with treatment efficacy and prognosis. We investigated the distribution and prognostic effect of mutations and tumor infiltrating lymphocyte (stromal TIL density) in young (≤35 years) and elderly (>65 years) early breast cancer patients. MATERIALS AND

methodsParaffin tumor genotypes of all clinical subtypes from 345 patients were examined.

resultsA total of 638 mutations were detected in 221 patients (64.1%). Compared to young, elderly patients presented with lower TIL density (p<0.001) but more TILs in TP53 mutated tumors (p=0.042). Mutation in one, rather than in 2 or more genes, conferred better outcome (DFS: HR=0.51, p=0.016; OS: HR=0.47, p=0.015) but the effect was age-independent.

conclusionThere are fewer TILs and different mutations patterns in tumors from elderly patients compared to young. Age and TIL-independent gene agnostic co-mutations affect patient outcome.

Indexed as

AdultAgedBiomarkers, TumorBreast NeoplasmsFemaleHumansLymphocytes, Tumor-InfiltratingMutationPrognosisBiomarkers, TumorAgeco-mutationgenotypeNGSstromal TIL density

Identifiers

PMID32108041
PMCPMC7078837
OpenAlexW3008827394

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.