Evidence map›Paper›PMID 32107625›Full record

ArticleJournal of cancer research and clinical oncology2020

Applicability of scoring systems predicting outcome of transarterial chemoembolization for hepatocellular carcinoma.

Marie Vogeler, Isabelle Mohr, Jan Pfeiffenberger, Simon David Sprengel, Miriam Klauss, Andreas Teufel, De-Hua Chang, Christoph Springfeld, Thomas Longerich, Uta Merle and 3 more

Abstract read
In one paragraph

Article in Journal of cancer research and clinical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Review
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  11. Quantitative washout in patients with hepatocellular carcinoma undergoing TACE: an imaging biomarker for predicting prognosis?Cancer imaging : the official publication of the International Cancer Imaging Society · 2022
    Article
  12. Article
  13. Article
  14. Antiviral Therapy Improves Hepatocellular Cancer Survival.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2021
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marie Vogeler *Internal Medicine IV, Heidelberg University Hospital, Heidelberg, Germany.
Isabelle Mohr *Internal Medicine IV, Heidelberg University Hospital, Heidelberg, Germany.
Jan PfeiffenbergerInternal Medicine IV, Heidelberg University Hospital, Heidelberg, Germany.
Simon David SprengelDepartment of Radiology, Heidelberg University Hospital, Heidelberg, Germany.
Miriam KlaussDepartment of Radiology, Heidelberg University Hospital, Heidelberg, Germany.
Andreas TeufelDivision of Hepatology, Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
De-Hua ChangDepartment of Radiology, Heidelberg University Hospital, Heidelberg, Germany.
Christoph SpringfeldDepartment of Medical Oncology, Heidelberg University Hospital, National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Thomas LongerichDepartment of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
Uta MerleInternal Medicine IV, Heidelberg University Hospital, Heidelberg, Germany.
Arianeb MehrabiDepartment of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, INF 110, 69120, Heidelberg, Germany.
Karl Heinz WeissInternal Medicine IV, Heidelberg University Hospital, Heidelberg, Germany.
Markus MiethDepartment of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, INF 110, 69120, Heidelberg, Germany. Markus.mieth@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-6331-9436

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSeveral scoring systems have been proposed to predict the outcome of transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). However, the application of these scores to a bridging to transplant setting is poorly validated. Evaluation of the applicability of prognostic scores for patients undergoing TACE in palliative intention vs. bridging therapy to liver transplantation (LT) is necessary.

methodsBetween 2008 and 2017, 148 patients with HCC received 492 completed TACE procedures (158 for bridging to transplant; 334 TACE procedures in palliative treatment intention at our center and were analyzed retrospectively. Scores (ART, CLIP, ALBI, APRI, SNACOR, HAP, STATE score, Child-Pugh, MELD, Okuda and BCLC) were calculated and evaluated for prediction of overall survival. ROC analysis was performed to assess prediction of 3-year survival and treatment discontinuation.

resultsIn patients receiving TACE in palliative intention most scores predicted OS in univariate analysis but only mSNACOR score (p = 0.006), State score (p < 0.001) and Child-Pugh score (p < 0.001) revealed statistical significance in the multivariate analysis. In the bridging to LT cohort only the BCLC score revealed statistical significance (p = 0.002).

conclusionsClinical usability of suggested scoring systems for TACE might be limited depending on the individual patient cohorts and the indication. Especially in patients receiving TACE as bridging to LT none of the scores showed sufficiently applicability. In our study Child-Pugh score, STATE score and mSNACOR score showed the best performance assessing OS in patients with TACE as palliative therapy.

Indexed as

AdultAgedAged, 80 and overCarboplatinCarcinoma, HepatocellularChemoembolization, TherapeuticCohort StudiesDoxorubicinEthiodized OilFemaleGermanyHumansLiver NeoplasmsLiver TransplantationMaleMiddle AgedCarboplatinDoxorubicinEthiodized OilEmbolizationLiver cancerStage migrationTACE

Identifiers

PMID32107625
PMCPMC7085483

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.